Cholesterol: A Gatekeeper of Male Fertility?

Cholesterol is essential for mammalian cell functions and integrity. It is an important structural component maintaining the permeability and fluidity of the cell membrane. The balance between synthesis and catabolism of cholesterol should be tightly regulated to ensure normal cellular processes. Ma...

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Autores principales: Sèdes, Lauriane, Thirouard, Laura, Maqdasy, Salwan, Garcia, Manon, Caira, Françoise, Lobaccaro, Jean-Marc A., Beaudoin, Claude, Volle, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060264/
https://www.ncbi.nlm.nih.gov/pubmed/30072948
http://dx.doi.org/10.3389/fendo.2018.00369
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author Sèdes, Lauriane
Thirouard, Laura
Maqdasy, Salwan
Garcia, Manon
Caira, Françoise
Lobaccaro, Jean-Marc A.
Beaudoin, Claude
Volle, David H.
author_facet Sèdes, Lauriane
Thirouard, Laura
Maqdasy, Salwan
Garcia, Manon
Caira, Françoise
Lobaccaro, Jean-Marc A.
Beaudoin, Claude
Volle, David H.
author_sort Sèdes, Lauriane
collection PubMed
description Cholesterol is essential for mammalian cell functions and integrity. It is an important structural component maintaining the permeability and fluidity of the cell membrane. The balance between synthesis and catabolism of cholesterol should be tightly regulated to ensure normal cellular processes. Male reproductive function has been demonstrated to be dependent on cholesterol homeostasis. Here we review data highlighting the impacts of cholesterol homeostasis on male fertility and the molecular mechanisms implicated through the signaling pathways of some nuclear receptors.
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spelling pubmed-60602642018-08-02 Cholesterol: A Gatekeeper of Male Fertility? Sèdes, Lauriane Thirouard, Laura Maqdasy, Salwan Garcia, Manon Caira, Françoise Lobaccaro, Jean-Marc A. Beaudoin, Claude Volle, David H. Front Endocrinol (Lausanne) Endocrinology Cholesterol is essential for mammalian cell functions and integrity. It is an important structural component maintaining the permeability and fluidity of the cell membrane. The balance between synthesis and catabolism of cholesterol should be tightly regulated to ensure normal cellular processes. Male reproductive function has been demonstrated to be dependent on cholesterol homeostasis. Here we review data highlighting the impacts of cholesterol homeostasis on male fertility and the molecular mechanisms implicated through the signaling pathways of some nuclear receptors. Frontiers Media S.A. 2018-07-19 /pmc/articles/PMC6060264/ /pubmed/30072948 http://dx.doi.org/10.3389/fendo.2018.00369 Text en Copyright © 2018 Sèdes, Thirouard, Maqdasy, Garcia, Caira, Lobaccaro, Beaudoin and Volle. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Sèdes, Lauriane
Thirouard, Laura
Maqdasy, Salwan
Garcia, Manon
Caira, Françoise
Lobaccaro, Jean-Marc A.
Beaudoin, Claude
Volle, David H.
Cholesterol: A Gatekeeper of Male Fertility?
title Cholesterol: A Gatekeeper of Male Fertility?
title_full Cholesterol: A Gatekeeper of Male Fertility?
title_fullStr Cholesterol: A Gatekeeper of Male Fertility?
title_full_unstemmed Cholesterol: A Gatekeeper of Male Fertility?
title_short Cholesterol: A Gatekeeper of Male Fertility?
title_sort cholesterol: a gatekeeper of male fertility?
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060264/
https://www.ncbi.nlm.nih.gov/pubmed/30072948
http://dx.doi.org/10.3389/fendo.2018.00369
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