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Are there any new reliable markers to detect renal injury in obese children?
Aim: The aim of this study was to examine the serum and urine levels of kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), osteopontin (OPN), matrix metalloproteinase-9 (MMP-9), and serum Cystatin-C to determine the renal effect of obesity in obese children. Methods...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060377/ https://www.ncbi.nlm.nih.gov/pubmed/30035656 http://dx.doi.org/10.1080/0886022X.2018.1489284 |
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author | Bostan Gayret, Özlem Taşdemir, Mehmet Erol, Meltem Tekin Nacaroğlu, Hikmet Zengi, Oğuzhan Yiğit, Özgül |
author_facet | Bostan Gayret, Özlem Taşdemir, Mehmet Erol, Meltem Tekin Nacaroğlu, Hikmet Zengi, Oğuzhan Yiğit, Özgül |
author_sort | Bostan Gayret, Özlem |
collection | PubMed |
description | Aim: The aim of this study was to examine the serum and urine levels of kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), osteopontin (OPN), matrix metalloproteinase-9 (MMP-9), and serum Cystatin-C to determine the renal effect of obesity in obese children. Methods: Seventy-two obese and 35 non-obese healthy children were included in this study. Blood pressure (BP) was evaluated with office measurement. Creatinine, cystatin C, lipids, fasting glucose, and insulin levels were measured, and homeostasis model assessment -insulin resistance (HOMA-IR) was calculated. The urine albumin/creatinine ratio was calculated. The serum and urine KIM-1, NGAL, OPN, and MMP-9 levels were measured. Results: Serum cystatin-C, triglyceride, and homeostasis model assessment-insulin resistance (HOMA-IR) index were found to be significantly higher in the obese group (p = .0001), and high-density lipoprotein (HDL) cholesterol was found to be significantly lower (p = .019) in the obese group. No significant differences were found in serum KIM-1, NGAL, OPN or MMP-9 levels between groups (p > .05). No significant differences were found in urine KIM-1 and MMP-9 levels (p > .05), Urine NGAL, and OPN levels were found significantly higher in obese groups (p < .05). Conclusions: According to our results, although serum KIM-1, NGAL, OPN, MMP-9, and urine MMP-9, urine KIM-1 do not appear to be ideal markers to evaluate renal injury in the early period of obesity, the serum levels of cystatin C and urine NGAL, urine OPN can be used as a good marker for assessing the renal effect of obesity which can lead end stage renal disease in pediatric population. |
format | Online Article Text |
id | pubmed-6060377 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-60603772018-07-27 Are there any new reliable markers to detect renal injury in obese children? Bostan Gayret, Özlem Taşdemir, Mehmet Erol, Meltem Tekin Nacaroğlu, Hikmet Zengi, Oğuzhan Yiğit, Özgül Ren Fail Clinical Study Aim: The aim of this study was to examine the serum and urine levels of kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), osteopontin (OPN), matrix metalloproteinase-9 (MMP-9), and serum Cystatin-C to determine the renal effect of obesity in obese children. Methods: Seventy-two obese and 35 non-obese healthy children were included in this study. Blood pressure (BP) was evaluated with office measurement. Creatinine, cystatin C, lipids, fasting glucose, and insulin levels were measured, and homeostasis model assessment -insulin resistance (HOMA-IR) was calculated. The urine albumin/creatinine ratio was calculated. The serum and urine KIM-1, NGAL, OPN, and MMP-9 levels were measured. Results: Serum cystatin-C, triglyceride, and homeostasis model assessment-insulin resistance (HOMA-IR) index were found to be significantly higher in the obese group (p = .0001), and high-density lipoprotein (HDL) cholesterol was found to be significantly lower (p = .019) in the obese group. No significant differences were found in serum KIM-1, NGAL, OPN or MMP-9 levels between groups (p > .05). No significant differences were found in urine KIM-1 and MMP-9 levels (p > .05), Urine NGAL, and OPN levels were found significantly higher in obese groups (p < .05). Conclusions: According to our results, although serum KIM-1, NGAL, OPN, MMP-9, and urine MMP-9, urine KIM-1 do not appear to be ideal markers to evaluate renal injury in the early period of obesity, the serum levels of cystatin C and urine NGAL, urine OPN can be used as a good marker for assessing the renal effect of obesity which can lead end stage renal disease in pediatric population. Taylor & Francis 2018-07-23 /pmc/articles/PMC6060377/ /pubmed/30035656 http://dx.doi.org/10.1080/0886022X.2018.1489284 Text en © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Bostan Gayret, Özlem Taşdemir, Mehmet Erol, Meltem Tekin Nacaroğlu, Hikmet Zengi, Oğuzhan Yiğit, Özgül Are there any new reliable markers to detect renal injury in obese children? |
title | Are there any new reliable markers to detect renal injury in obese children? |
title_full | Are there any new reliable markers to detect renal injury in obese children? |
title_fullStr | Are there any new reliable markers to detect renal injury in obese children? |
title_full_unstemmed | Are there any new reliable markers to detect renal injury in obese children? |
title_short | Are there any new reliable markers to detect renal injury in obese children? |
title_sort | are there any new reliable markers to detect renal injury in obese children? |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060377/ https://www.ncbi.nlm.nih.gov/pubmed/30035656 http://dx.doi.org/10.1080/0886022X.2018.1489284 |
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