Synthesis and pharmacological evaluation of novel isoquinoline N-sulphonylhydrazones designed as ROCK inhibitors

In this study, we synthesized a new congener series of N-sulphonylhydrazones designed as candidate ROCK inhibitors using the molecular hybridization of the clinically approved drug fasudil (1) and the IKK-β inhibitor LASSBio-1524 (2). Among the synthesized compounds, the N-methylated derivative 11 (...

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Detalles Bibliográficos
Autores principales: de Oliveira, Ramon Guerra, Guerra, Fabiana Sélos, Mermelstein, Cláudia dos Santos, Fernandes, Patrícia Dias, Bastos, Isadora Tairinne de Sena, Costa, Fanny Nascimento, Barroso, Regina Cely Rodrigues, Ferreira, Fabio Furlan, Fraga, Carlos Alberto Manssour
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060383/
https://www.ncbi.nlm.nih.gov/pubmed/30044647
http://dx.doi.org/10.1080/14756366.2018.1490732

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