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Urine miR-21-5p as a potential biomarker for predicting effectiveness of tadalafil in benign prostatic hyperplasia
AIM: To investigate whether urine levels of miRNAs that regulate the function of endothelial cells are associated with effectiveness in benign prostatic hyperplasia (BPH) patients treated with a phosphodiesterase type 5 inhibitor, tadalafil. PATIENTS & METHODS: We measured urine levels of three...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Future Science Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060390/ https://www.ncbi.nlm.nih.gov/pubmed/30057782 http://dx.doi.org/10.4155/fsoa-2018-0012 |
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author | Tanaka, Tomoaki Minami, Akinori Tashiro, Kouichiro Yoshida, Naomasa Tohda, Akira Yamakoshi, Yasuo Yasumoto, Ryoji Sugita, Shozo Nakatani, Tatsuya |
author_facet | Tanaka, Tomoaki Minami, Akinori Tashiro, Kouichiro Yoshida, Naomasa Tohda, Akira Yamakoshi, Yasuo Yasumoto, Ryoji Sugita, Shozo Nakatani, Tatsuya |
author_sort | Tanaka, Tomoaki |
collection | PubMed |
description | AIM: To investigate whether urine levels of miRNAs that regulate the function of endothelial cells are associated with effectiveness in benign prostatic hyperplasia (BPH) patients treated with a phosphodiesterase type 5 inhibitor, tadalafil. PATIENTS & METHODS: We measured urine levels of three miRNAs (miR-21-5p, miR-126-5p & miR-155-5p) in 55 BPH patients before and after tadalafil administration to understand its effectiveness. RESULTS: Baseline urine miR-21-5p level was an independent predictor of response to tadalafil in multivariate regression analysis (odds ratio: 0.28; 95% CI: 0.10–0.77; p = 0.014). Receiver operator curve analysis revealed that baseline urine miR-21-5p could serve as a predictor of response (area under curve: 0.85; 95% CI: 0.75–0.95; p < 0.001). CONCLUSION: Urine miR-21-5p could serve as a biomarker in predicting response of tadalafil for BPH. |
format | Online Article Text |
id | pubmed-6060390 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Future Science Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-60603902018-07-27 Urine miR-21-5p as a potential biomarker for predicting effectiveness of tadalafil in benign prostatic hyperplasia Tanaka, Tomoaki Minami, Akinori Tashiro, Kouichiro Yoshida, Naomasa Tohda, Akira Yamakoshi, Yasuo Yasumoto, Ryoji Sugita, Shozo Nakatani, Tatsuya Future Sci OA Research Article AIM: To investigate whether urine levels of miRNAs that regulate the function of endothelial cells are associated with effectiveness in benign prostatic hyperplasia (BPH) patients treated with a phosphodiesterase type 5 inhibitor, tadalafil. PATIENTS & METHODS: We measured urine levels of three miRNAs (miR-21-5p, miR-126-5p & miR-155-5p) in 55 BPH patients before and after tadalafil administration to understand its effectiveness. RESULTS: Baseline urine miR-21-5p level was an independent predictor of response to tadalafil in multivariate regression analysis (odds ratio: 0.28; 95% CI: 0.10–0.77; p = 0.014). Receiver operator curve analysis revealed that baseline urine miR-21-5p could serve as a predictor of response (area under curve: 0.85; 95% CI: 0.75–0.95; p < 0.001). CONCLUSION: Urine miR-21-5p could serve as a biomarker in predicting response of tadalafil for BPH. Future Science Ltd 2018-03-15 /pmc/articles/PMC6060390/ /pubmed/30057782 http://dx.doi.org/10.4155/fsoa-2018-0012 Text en © 2018 Tomoaki Tanaka This work is licensed under a Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Research Article Tanaka, Tomoaki Minami, Akinori Tashiro, Kouichiro Yoshida, Naomasa Tohda, Akira Yamakoshi, Yasuo Yasumoto, Ryoji Sugita, Shozo Nakatani, Tatsuya Urine miR-21-5p as a potential biomarker for predicting effectiveness of tadalafil in benign prostatic hyperplasia |
title | Urine miR-21-5p as a potential biomarker for predicting effectiveness of tadalafil in benign prostatic hyperplasia |
title_full | Urine miR-21-5p as a potential biomarker for predicting effectiveness of tadalafil in benign prostatic hyperplasia |
title_fullStr | Urine miR-21-5p as a potential biomarker for predicting effectiveness of tadalafil in benign prostatic hyperplasia |
title_full_unstemmed | Urine miR-21-5p as a potential biomarker for predicting effectiveness of tadalafil in benign prostatic hyperplasia |
title_short | Urine miR-21-5p as a potential biomarker for predicting effectiveness of tadalafil in benign prostatic hyperplasia |
title_sort | urine mir-21-5p as a potential biomarker for predicting effectiveness of tadalafil in benign prostatic hyperplasia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060390/ https://www.ncbi.nlm.nih.gov/pubmed/30057782 http://dx.doi.org/10.4155/fsoa-2018-0012 |
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