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The different axes of the mammalian mitochondrial unfolded protein response
Mitochondria are sensitive to numerous environmental stresses, which can lead to activation of mitochondrial stress responses (MSRs). Of particular recent interest has been the mitochondrial unfolded protein response (UPR(mt)), activated to restore protein homeostasis (proteostasis) upon mitochondri...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060479/ https://www.ncbi.nlm.nih.gov/pubmed/30049264 http://dx.doi.org/10.1186/s12915-018-0548-x |
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author | Münch, Christian |
author_facet | Münch, Christian |
author_sort | Münch, Christian |
collection | PubMed |
description | Mitochondria are sensitive to numerous environmental stresses, which can lead to activation of mitochondrial stress responses (MSRs). Of particular recent interest has been the mitochondrial unfolded protein response (UPR(mt)), activated to restore protein homeostasis (proteostasis) upon mitochondrial protein misfolding. Several axes of the UPR(mt) have been described, creating some confusion as to the nature of the different responses. While distinct molecularly, these different axes are likely mutually beneficial and activated in parallel. This review aims at describing and distinguishing the different mammalian MSR/UPR(mt) axes to define key processes and members and to examine the involvement of protein misfolding. |
format | Online Article Text |
id | pubmed-6060479 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-60604792018-07-31 The different axes of the mammalian mitochondrial unfolded protein response Münch, Christian BMC Biol Review Mitochondria are sensitive to numerous environmental stresses, which can lead to activation of mitochondrial stress responses (MSRs). Of particular recent interest has been the mitochondrial unfolded protein response (UPR(mt)), activated to restore protein homeostasis (proteostasis) upon mitochondrial protein misfolding. Several axes of the UPR(mt) have been described, creating some confusion as to the nature of the different responses. While distinct molecularly, these different axes are likely mutually beneficial and activated in parallel. This review aims at describing and distinguishing the different mammalian MSR/UPR(mt) axes to define key processes and members and to examine the involvement of protein misfolding. BioMed Central 2018-07-26 /pmc/articles/PMC6060479/ /pubmed/30049264 http://dx.doi.org/10.1186/s12915-018-0548-x Text en © Münch et al. 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Münch, Christian The different axes of the mammalian mitochondrial unfolded protein response |
title | The different axes of the mammalian mitochondrial unfolded protein response |
title_full | The different axes of the mammalian mitochondrial unfolded protein response |
title_fullStr | The different axes of the mammalian mitochondrial unfolded protein response |
title_full_unstemmed | The different axes of the mammalian mitochondrial unfolded protein response |
title_short | The different axes of the mammalian mitochondrial unfolded protein response |
title_sort | different axes of the mammalian mitochondrial unfolded protein response |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060479/ https://www.ncbi.nlm.nih.gov/pubmed/30049264 http://dx.doi.org/10.1186/s12915-018-0548-x |
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