Cargando…
Critical role of FOXO3a in carcinogenesis
FOXO3a is a member of the FOXO subfamily of forkhead transcription factors that mediate a variety of cellular processes including apoptosis, proliferation, cell cycle progression, DNA damage and tumorigenesis. It also responds to several cellular stresses such as UV irradiation and oxidative stress....
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060507/ https://www.ncbi.nlm.nih.gov/pubmed/30045773 http://dx.doi.org/10.1186/s12943-018-0856-3 |
_version_ | 1783342045608280064 |
---|---|
author | Liu, Ying Ao, Xiang Ding, Wei Ponnusamy, Murugavel Wu, Wei Hao, Xiaodan Yu, Wanpeng Wang, Yifei Li, Peifeng Wang, Jianxun |
author_facet | Liu, Ying Ao, Xiang Ding, Wei Ponnusamy, Murugavel Wu, Wei Hao, Xiaodan Yu, Wanpeng Wang, Yifei Li, Peifeng Wang, Jianxun |
author_sort | Liu, Ying |
collection | PubMed |
description | FOXO3a is a member of the FOXO subfamily of forkhead transcription factors that mediate a variety of cellular processes including apoptosis, proliferation, cell cycle progression, DNA damage and tumorigenesis. It also responds to several cellular stresses such as UV irradiation and oxidative stress. The function of FOXO3a is regulated by a complex network of processes, including post-transcriptional suppression by microRNAs (miRNAs), post-translational modifications (PTMs) and protein–protein interactions. FOXO3a is widely implicated in a variety of diseases, particularly in malignancy of breast, liver, colon, prostate, bladder, and nasopharyngeal cancers. Emerging evidences indicate that FOXO3a acts as a tumor suppressor in cancer. FOXO3a is frequently inactivated in cancer cell lines by mutation of the FOXO3a gene or cytoplasmic sequestration of FOXO3a protein. And its inactivation is associated with the initiation and progression of cancer. In experimental studies, overexpression of FOXO3a inhibits the proliferation, tumorigenic potential, and invasiveness of cancer cells, while silencing of FOXO3a results in marked attenuation in protection against tumorigenesis. The role of FOXO3a in both normal physiology as well as in cancer development have presented a great challenge to formulating an effective therapeutic strategy for cancer. In this review, we summarize the recent findings and overview of the current understanding of the influence of FOXO3a in cancer development and progression. |
format | Online Article Text |
id | pubmed-6060507 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-60605072018-07-31 Critical role of FOXO3a in carcinogenesis Liu, Ying Ao, Xiang Ding, Wei Ponnusamy, Murugavel Wu, Wei Hao, Xiaodan Yu, Wanpeng Wang, Yifei Li, Peifeng Wang, Jianxun Mol Cancer Review FOXO3a is a member of the FOXO subfamily of forkhead transcription factors that mediate a variety of cellular processes including apoptosis, proliferation, cell cycle progression, DNA damage and tumorigenesis. It also responds to several cellular stresses such as UV irradiation and oxidative stress. The function of FOXO3a is regulated by a complex network of processes, including post-transcriptional suppression by microRNAs (miRNAs), post-translational modifications (PTMs) and protein–protein interactions. FOXO3a is widely implicated in a variety of diseases, particularly in malignancy of breast, liver, colon, prostate, bladder, and nasopharyngeal cancers. Emerging evidences indicate that FOXO3a acts as a tumor suppressor in cancer. FOXO3a is frequently inactivated in cancer cell lines by mutation of the FOXO3a gene or cytoplasmic sequestration of FOXO3a protein. And its inactivation is associated with the initiation and progression of cancer. In experimental studies, overexpression of FOXO3a inhibits the proliferation, tumorigenic potential, and invasiveness of cancer cells, while silencing of FOXO3a results in marked attenuation in protection against tumorigenesis. The role of FOXO3a in both normal physiology as well as in cancer development have presented a great challenge to formulating an effective therapeutic strategy for cancer. In this review, we summarize the recent findings and overview of the current understanding of the influence of FOXO3a in cancer development and progression. BioMed Central 2018-07-25 /pmc/articles/PMC6060507/ /pubmed/30045773 http://dx.doi.org/10.1186/s12943-018-0856-3 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Liu, Ying Ao, Xiang Ding, Wei Ponnusamy, Murugavel Wu, Wei Hao, Xiaodan Yu, Wanpeng Wang, Yifei Li, Peifeng Wang, Jianxun Critical role of FOXO3a in carcinogenesis |
title | Critical role of FOXO3a in carcinogenesis |
title_full | Critical role of FOXO3a in carcinogenesis |
title_fullStr | Critical role of FOXO3a in carcinogenesis |
title_full_unstemmed | Critical role of FOXO3a in carcinogenesis |
title_short | Critical role of FOXO3a in carcinogenesis |
title_sort | critical role of foxo3a in carcinogenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060507/ https://www.ncbi.nlm.nih.gov/pubmed/30045773 http://dx.doi.org/10.1186/s12943-018-0856-3 |
work_keys_str_mv | AT liuying criticalroleoffoxo3aincarcinogenesis AT aoxiang criticalroleoffoxo3aincarcinogenesis AT dingwei criticalroleoffoxo3aincarcinogenesis AT ponnusamymurugavel criticalroleoffoxo3aincarcinogenesis AT wuwei criticalroleoffoxo3aincarcinogenesis AT haoxiaodan criticalroleoffoxo3aincarcinogenesis AT yuwanpeng criticalroleoffoxo3aincarcinogenesis AT wangyifei criticalroleoffoxo3aincarcinogenesis AT lipeifeng criticalroleoffoxo3aincarcinogenesis AT wangjianxun criticalroleoffoxo3aincarcinogenesis |