Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network

BACKGROUND: Mutations in amyloid precursor protein (APP), presenilin 1 (PSEN1) and presenilin 2 (PSEN2) cause autosomal dominant forms of Alzheimer disease (ADAD). More than 280 pathogenic mutations have been reported in APP, PSEN1, and PSEN2. However, understanding of the basic biological mechanism...

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Detalles Bibliográficos
Autores principales: Karch, Celeste M., Hernández, Damián, Wang, Jen-Chyong, Marsh, Jacob, Hewitt, Alex W., Hsu, Simon, Norton, Joanne, Levitch, Denise, Donahue, Tamara, Sigurdson, Wendy, Ghetti, Bernardino, Farlow, Martin, Chhatwal, Jasmeer, Berman, Sarah, Cruchaga, Carlos, Morris, John C., Bateman, Randall J., Pébay, Alice, Goate, Alison M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060509/
https://www.ncbi.nlm.nih.gov/pubmed/30045758
http://dx.doi.org/10.1186/s13195-018-0400-0

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