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Collision metastasis of prostatic adenocarcinoma and urothelial carcinoma of the bladder

The incidence of concomitant prostate adenocarcinoma found in patients with muscle-invasive bladder carcinoma is not uncommon, reaching up to 21%–28%. However, the presence of collision metastasis involving prostate cancer and bladder cancer within the same lymph node is exceedingly rare, with only...

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Autores principales: Sellman, David P., Peard, Leslie, Simpson, Greg, Lancaster, Katrina, Kavuri, Sravan, Terris, Martha, Madi, Rabbi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060602/
https://www.ncbi.nlm.nih.gov/pubmed/30089999
http://dx.doi.org/10.4103/UA.UA_97_17
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author Sellman, David P.
Peard, Leslie
Simpson, Greg
Lancaster, Katrina
Kavuri, Sravan
Terris, Martha
Madi, Rabbi
author_facet Sellman, David P.
Peard, Leslie
Simpson, Greg
Lancaster, Katrina
Kavuri, Sravan
Terris, Martha
Madi, Rabbi
author_sort Sellman, David P.
collection PubMed
description The incidence of concomitant prostate adenocarcinoma found in patients with muscle-invasive bladder carcinoma is not uncommon, reaching up to 21%–28%. However, the presence of collision metastasis involving prostate cancer and bladder cancer within the same lymph node is exceedingly rare, with only 5 cases reported to date in the literature. We report a case of collision metastasis of prostate adenocarcinoma and urothelial carcinoma of the bladder in a 73-year-old man who underwent cystoprostatectomy with bilateral pelvic lymph node dissection for high-grade muscle-invasive urothelial carcinoma. Final pathology revealed a pT3aN2 high-grade urothelial carcinoma and pT3N1 Gleason 4 + 4 = 8 adenocarcinoma of the prostate with 12/40 pelvic lymph nodes positive for urothelial carcinoma. One node was positive for both urothelial carcinoma and prostate adenocarcinoma, confirmed by positive staining by p40 and prostate specific antigen(PSA), respectively. Immunohistochemistry is the sole method of confirming collision metastasis of two primary cancers. In this case, we describe immunohistochemical markers for urothelial carcinoma and prostate adenocarcinoma and their clinical implications. One month postoperatively, our patient began adjuvant leuprolide therapy and cycle 1 of gemcitabine and cisplatin chemotherapy, which he is tolerating well.
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spelling pubmed-60606022018-08-08 Collision metastasis of prostatic adenocarcinoma and urothelial carcinoma of the bladder Sellman, David P. Peard, Leslie Simpson, Greg Lancaster, Katrina Kavuri, Sravan Terris, Martha Madi, Rabbi Urol Ann Case Report The incidence of concomitant prostate adenocarcinoma found in patients with muscle-invasive bladder carcinoma is not uncommon, reaching up to 21%–28%. However, the presence of collision metastasis involving prostate cancer and bladder cancer within the same lymph node is exceedingly rare, with only 5 cases reported to date in the literature. We report a case of collision metastasis of prostate adenocarcinoma and urothelial carcinoma of the bladder in a 73-year-old man who underwent cystoprostatectomy with bilateral pelvic lymph node dissection for high-grade muscle-invasive urothelial carcinoma. Final pathology revealed a pT3aN2 high-grade urothelial carcinoma and pT3N1 Gleason 4 + 4 = 8 adenocarcinoma of the prostate with 12/40 pelvic lymph nodes positive for urothelial carcinoma. One node was positive for both urothelial carcinoma and prostate adenocarcinoma, confirmed by positive staining by p40 and prostate specific antigen(PSA), respectively. Immunohistochemistry is the sole method of confirming collision metastasis of two primary cancers. In this case, we describe immunohistochemical markers for urothelial carcinoma and prostate adenocarcinoma and their clinical implications. One month postoperatively, our patient began adjuvant leuprolide therapy and cycle 1 of gemcitabine and cisplatin chemotherapy, which he is tolerating well. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC6060602/ /pubmed/30089999 http://dx.doi.org/10.4103/UA.UA_97_17 Text en Copyright: © 2018 Urology Annals http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Sellman, David P.
Peard, Leslie
Simpson, Greg
Lancaster, Katrina
Kavuri, Sravan
Terris, Martha
Madi, Rabbi
Collision metastasis of prostatic adenocarcinoma and urothelial carcinoma of the bladder
title Collision metastasis of prostatic adenocarcinoma and urothelial carcinoma of the bladder
title_full Collision metastasis of prostatic adenocarcinoma and urothelial carcinoma of the bladder
title_fullStr Collision metastasis of prostatic adenocarcinoma and urothelial carcinoma of the bladder
title_full_unstemmed Collision metastasis of prostatic adenocarcinoma and urothelial carcinoma of the bladder
title_short Collision metastasis of prostatic adenocarcinoma and urothelial carcinoma of the bladder
title_sort collision metastasis of prostatic adenocarcinoma and urothelial carcinoma of the bladder
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060602/
https://www.ncbi.nlm.nih.gov/pubmed/30089999
http://dx.doi.org/10.4103/UA.UA_97_17
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