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Programmed Death Receptor 1 (PD1) Knockout and Human Telomerase Reverse Transcriptase (hTERT) Transduction Can Enhance Persistence and Antitumor Efficacy of Cytokine-Induced Killer Cells Against Hepatocellular Carcinoma

BACKGROUND: The weak antitumor efficacy and limited lifespan are the main obstacles that hinder the therapeutic effect of cytokine-induced killer (CIK) cell immunotherapy. In the study, we enhanced the persistence and the antitumor efficacy of CIK cell through PD-1 knockout and hTERT transduction. M...

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Detalles Bibliográficos
Autores principales:	Huang, Kanghua, Sun, Bowen, Luo, Nan, Guo, Huahu, Hu, Jili, Peng, Jirun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Scientific Literature, Inc. 2018
Materias:	Lab/In Vitro Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060692/ https://www.ncbi.nlm.nih.gov/pubmed/29967316 http://dx.doi.org/10.12659/MSM.910903

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