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The clinical significance of 10-m walk test standardizations in Parkinson’s disease

BACKGROUND: The 10-m walk test (10MWT) is a widely used measure of gait speed in Parkinson’s disease (PD). However, it is unclear if different standardizations of its conduct impact test results. AIM OF THE STUDY: We examined the clinical significance of two aspects of the standardization of the 10M...

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Autores principales: Lindholm, Beata, Nilsson, Maria H., Hansson, Oskar, Hagell, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060742/
https://www.ncbi.nlm.nih.gov/pubmed/29876762
http://dx.doi.org/10.1007/s00415-018-8921-9
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author Lindholm, Beata
Nilsson, Maria H.
Hansson, Oskar
Hagell, Peter
author_facet Lindholm, Beata
Nilsson, Maria H.
Hansson, Oskar
Hagell, Peter
author_sort Lindholm, Beata
collection PubMed
description BACKGROUND: The 10-m walk test (10MWT) is a widely used measure of gait speed in Parkinson’s disease (PD). However, it is unclear if different standardizations of its conduct impact test results. AIM OF THE STUDY: We examined the clinical significance of two aspects of the standardization of the 10MWT in mild PD: static vs. dynamic start, and a single vs. repeated trials. Implications for fall prediction were also explored. METHODS: 151 people with PD (mean age and PD duration, 68 and 4 years, respectively) completed the 10MWT in comfortable gait speed with static and dynamic start (two trials each), and gait speed (m/s) was recorded. Participants then registered all prospective falls for 6 months. RESULTS: Absolute mean differences between outcomes from the various test conditions ranged between 0.016 and 0.040 m/s (effect sizes, 0.06–0.14) with high levels of agreement (intra-class correlation coefficients, 0.932–0.987) and small standard errors of measurement (0.032–0.076 m/s). Receiver operating characteristic curves showed similar discriminate abilities for prediction of future falls across conditions (areas under curves, 0.70–0.73). Cut-off points were estimated at 1.1–1.2 m/s. CONCLUSIONS: Different 10MWT standardizations yield very similar results, suggesting that there is no practical need for an acceleration distance or repeated trials when conducting this test in mild PD.
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spelling pubmed-60607422018-08-09 The clinical significance of 10-m walk test standardizations in Parkinson’s disease Lindholm, Beata Nilsson, Maria H. Hansson, Oskar Hagell, Peter J Neurol Original Communication BACKGROUND: The 10-m walk test (10MWT) is a widely used measure of gait speed in Parkinson’s disease (PD). However, it is unclear if different standardizations of its conduct impact test results. AIM OF THE STUDY: We examined the clinical significance of two aspects of the standardization of the 10MWT in mild PD: static vs. dynamic start, and a single vs. repeated trials. Implications for fall prediction were also explored. METHODS: 151 people with PD (mean age and PD duration, 68 and 4 years, respectively) completed the 10MWT in comfortable gait speed with static and dynamic start (two trials each), and gait speed (m/s) was recorded. Participants then registered all prospective falls for 6 months. RESULTS: Absolute mean differences between outcomes from the various test conditions ranged between 0.016 and 0.040 m/s (effect sizes, 0.06–0.14) with high levels of agreement (intra-class correlation coefficients, 0.932–0.987) and small standard errors of measurement (0.032–0.076 m/s). Receiver operating characteristic curves showed similar discriminate abilities for prediction of future falls across conditions (areas under curves, 0.70–0.73). Cut-off points were estimated at 1.1–1.2 m/s. CONCLUSIONS: Different 10MWT standardizations yield very similar results, suggesting that there is no practical need for an acceleration distance or repeated trials when conducting this test in mild PD. Springer Berlin Heidelberg 2018-06-06 2018 /pmc/articles/PMC6060742/ /pubmed/29876762 http://dx.doi.org/10.1007/s00415-018-8921-9 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Communication
Lindholm, Beata
Nilsson, Maria H.
Hansson, Oskar
Hagell, Peter
The clinical significance of 10-m walk test standardizations in Parkinson’s disease
title The clinical significance of 10-m walk test standardizations in Parkinson’s disease
title_full The clinical significance of 10-m walk test standardizations in Parkinson’s disease
title_fullStr The clinical significance of 10-m walk test standardizations in Parkinson’s disease
title_full_unstemmed The clinical significance of 10-m walk test standardizations in Parkinson’s disease
title_short The clinical significance of 10-m walk test standardizations in Parkinson’s disease
title_sort clinical significance of 10-m walk test standardizations in parkinson’s disease
topic Original Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060742/
https://www.ncbi.nlm.nih.gov/pubmed/29876762
http://dx.doi.org/10.1007/s00415-018-8921-9
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