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Reduced and optimized trial designs for drugs described by a target mediated drug disposition model
Monoclonal antibodies against soluble targets are often rich and include the sampling of multiple analytes over a lengthy period of time. Predictive models built on data obtained in such studies can be useful in all drug development phases. If adequate model predictions can be maintained with a redu...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061097/ https://www.ncbi.nlm.nih.gov/pubmed/29948794 http://dx.doi.org/10.1007/s10928-018-9594-9 |