The chemo- enzymatic synthesis of labeled l-amino acids and some of their derivatives

This review compiles the combined chemical and enzymatic synthesis of aromatic l-amino acids (l-phenylalanine, l-tyrosine, l-DOPA, l-tryptophan, and their derivatives and precursors) specifically labeled with carbon and hydrogen isotopes, which were elaborated in our research group by the past 20 ye...

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Autores principales: Pająk, Małgorzata, Pałka, Katarzyna, Winnicka, Elżbieta, Kańska, Marianna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061101/
https://www.ncbi.nlm.nih.gov/pubmed/30100649
http://dx.doi.org/10.1007/s10967-018-5932-z
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author Pająk, Małgorzata
Pałka, Katarzyna
Winnicka, Elżbieta
Kańska, Marianna
author_facet Pająk, Małgorzata
Pałka, Katarzyna
Winnicka, Elżbieta
Kańska, Marianna
author_sort Pająk, Małgorzata
collection PubMed
description This review compiles the combined chemical and enzymatic synthesis of aromatic l-amino acids (l-phenylalanine, l-tyrosine, l-DOPA, l-tryptophan, and their derivatives and precursors) specifically labeled with carbon and hydrogen isotopes, which were elaborated in our research group by the past 20 years. These compounds could be then employed to characterize the mechanisms of enzymatic reactions via kinetic and solvent isotope effects methods.
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spelling pubmed-60611012018-08-09 The chemo- enzymatic synthesis of labeled l-amino acids and some of their derivatives Pająk, Małgorzata Pałka, Katarzyna Winnicka, Elżbieta Kańska, Marianna J Radioanal Nucl Chem Article This review compiles the combined chemical and enzymatic synthesis of aromatic l-amino acids (l-phenylalanine, l-tyrosine, l-DOPA, l-tryptophan, and their derivatives and precursors) specifically labeled with carbon and hydrogen isotopes, which were elaborated in our research group by the past 20 years. These compounds could be then employed to characterize the mechanisms of enzymatic reactions via kinetic and solvent isotope effects methods. Springer International Publishing 2018-05-30 2018 /pmc/articles/PMC6061101/ /pubmed/30100649 http://dx.doi.org/10.1007/s10967-018-5932-z Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Pająk, Małgorzata
Pałka, Katarzyna
Winnicka, Elżbieta
Kańska, Marianna
The chemo- enzymatic synthesis of labeled l-amino acids and some of their derivatives
title The chemo- enzymatic synthesis of labeled l-amino acids and some of their derivatives
title_full The chemo- enzymatic synthesis of labeled l-amino acids and some of their derivatives
title_fullStr The chemo- enzymatic synthesis of labeled l-amino acids and some of their derivatives
title_full_unstemmed The chemo- enzymatic synthesis of labeled l-amino acids and some of their derivatives
title_short The chemo- enzymatic synthesis of labeled l-amino acids and some of their derivatives
title_sort chemo- enzymatic synthesis of labeled l-amino acids and some of their derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061101/
https://www.ncbi.nlm.nih.gov/pubmed/30100649
http://dx.doi.org/10.1007/s10967-018-5932-z
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