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ISCEV extended protocol for the photopic On–Off ERG
The International Society for Clinical Electrophysiology of Vision (ISCEV) standard for full-field electroretinography (ERG) describes a minimum procedure, but encourages more extensive testing. This ISCEV extended protocol describes an extension to the ERG standard, namely the photopic On–Off ERG,...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061123/ https://www.ncbi.nlm.nih.gov/pubmed/29934802 http://dx.doi.org/10.1007/s10633-018-9645-y |
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author | Sustar, Maja Holder, Graham E. Kremers, Jan Barnes, Claire S. Lei, Bo Khan, Naheed W. Robson, Anthony G. |
author_facet | Sustar, Maja Holder, Graham E. Kremers, Jan Barnes, Claire S. Lei, Bo Khan, Naheed W. Robson, Anthony G. |
author_sort | Sustar, Maja |
collection | PubMed |
description | The International Society for Clinical Electrophysiology of Vision (ISCEV) standard for full-field electroretinography (ERG) describes a minimum procedure, but encourages more extensive testing. This ISCEV extended protocol describes an extension to the ERG standard, namely the photopic On–Off ERG, and outlines common clinical applications. A light stimulus duration of 150–200 ms is used in the presence of a rod-suppressing background to elicit cone-driven On- and Off-system ERG components. The On-response occurs after the stimulus onset and has a negative a-wave and positive b-wave. The Off d-wave is a positive component evoked by stimulus offset. Common diagnoses that may benefit from additional photopic On–Off ERG testing include retinal dystrophies and retinal disorders that cause dysfunction at a level that is post-phototransduction or post-receptoral. On–Off ERGs assess the relative involvement of On- and Off-systems and may be of use in the diagnosis of disorders such as complete and incomplete congenital stationary night blindness (complete and incomplete CSNB), melanoma-associated retinopathy, and some forms of autoimmune retinopathy. The photopic On–Off ERGs may also be useful in X-linked retinoschisis, Batten disease, Duchenne muscular dystrophy, spinocerebellar degeneration, quinine toxicity, and other retinal disorders. |
format | Online Article Text |
id | pubmed-6061123 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-60611232018-08-09 ISCEV extended protocol for the photopic On–Off ERG Sustar, Maja Holder, Graham E. Kremers, Jan Barnes, Claire S. Lei, Bo Khan, Naheed W. Robson, Anthony G. Doc Ophthalmol ISCEV Standards The International Society for Clinical Electrophysiology of Vision (ISCEV) standard for full-field electroretinography (ERG) describes a minimum procedure, but encourages more extensive testing. This ISCEV extended protocol describes an extension to the ERG standard, namely the photopic On–Off ERG, and outlines common clinical applications. A light stimulus duration of 150–200 ms is used in the presence of a rod-suppressing background to elicit cone-driven On- and Off-system ERG components. The On-response occurs after the stimulus onset and has a negative a-wave and positive b-wave. The Off d-wave is a positive component evoked by stimulus offset. Common diagnoses that may benefit from additional photopic On–Off ERG testing include retinal dystrophies and retinal disorders that cause dysfunction at a level that is post-phototransduction or post-receptoral. On–Off ERGs assess the relative involvement of On- and Off-systems and may be of use in the diagnosis of disorders such as complete and incomplete congenital stationary night blindness (complete and incomplete CSNB), melanoma-associated retinopathy, and some forms of autoimmune retinopathy. The photopic On–Off ERGs may also be useful in X-linked retinoschisis, Batten disease, Duchenne muscular dystrophy, spinocerebellar degeneration, quinine toxicity, and other retinal disorders. Springer Berlin Heidelberg 2018-06-22 2018 /pmc/articles/PMC6061123/ /pubmed/29934802 http://dx.doi.org/10.1007/s10633-018-9645-y Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | ISCEV Standards Sustar, Maja Holder, Graham E. Kremers, Jan Barnes, Claire S. Lei, Bo Khan, Naheed W. Robson, Anthony G. ISCEV extended protocol for the photopic On–Off ERG |
title | ISCEV extended protocol for the photopic On–Off ERG |
title_full | ISCEV extended protocol for the photopic On–Off ERG |
title_fullStr | ISCEV extended protocol for the photopic On–Off ERG |
title_full_unstemmed | ISCEV extended protocol for the photopic On–Off ERG |
title_short | ISCEV extended protocol for the photopic On–Off ERG |
title_sort | iscev extended protocol for the photopic on–off erg |
topic | ISCEV Standards |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061123/ https://www.ncbi.nlm.nih.gov/pubmed/29934802 http://dx.doi.org/10.1007/s10633-018-9645-y |
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