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NK and NKT-Like Cells in Patients with Recurrent Furunculosis
To analyze changes in the number and percentage of NK and NKT-like cells in relation to other immune cells as well as to examine associations between increased susceptibility to infections and NK and NKT-like status in patients with recurrent furunculosis (RF) and healthy controls. Thirty patients w...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061139/ https://www.ncbi.nlm.nih.gov/pubmed/29236128 http://dx.doi.org/10.1007/s00005-017-0500-8 |
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author | Nowicka, Danuta Grywalska, Ewelina Fitas, Elżbieta Mielnik, Michał Roliński, Jacek |
author_facet | Nowicka, Danuta Grywalska, Ewelina Fitas, Elżbieta Mielnik, Michał Roliński, Jacek |
author_sort | Nowicka, Danuta |
collection | PubMed |
description | To analyze changes in the number and percentage of NK and NKT-like cells in relation to other immune cells as well as to examine associations between increased susceptibility to infections and NK and NKT-like status in patients with recurrent furunculosis (RF) and healthy controls. Thirty patients with RF and 20 healthy age- and sex-matched volunteers were recruited. Blood samples were examined. Lymphocyte count and cytometric analyses were conducted. For statistical analysis, the Student’s t test, F test, and Brown–Forsythe test were used for comparison between groups of variables. Associations were assessed with Pearson coefficient. Patients with RF had lower lymphocyte count than controls. Additionally, they presented with the following changes in the blood picture: a significant increase in the number of NK cells with a CD3(+)CD16(+)CD56(+) phenotype; a proportional increase in the number and percentage of NKT-like cells with a CD3(+)CD16(+)CD56(+) phenotype; a significant decrease in the number and percentage of T CD3(+) cells. The number of NK cells was strongly positively correlated with the number of CD3 cells (r = 0.6162). The number of NKT cells was strongly positively correlated with CD3 cells (r = 0.6885) and CD3CD8 cells (r = 0.5465). Periodic exacerbations in RF are associated with the development of furuncles, which are a result of many already discovered as well as just being examined mechanisms. One of them is a significant increase in the number and most likely activation of NK and NKT-like cells during the formation of the inflammatory process and furuncles. |
format | Online Article Text |
id | pubmed-6061139 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-60611392018-08-09 NK and NKT-Like Cells in Patients with Recurrent Furunculosis Nowicka, Danuta Grywalska, Ewelina Fitas, Elżbieta Mielnik, Michał Roliński, Jacek Arch Immunol Ther Exp (Warsz) Original Article To analyze changes in the number and percentage of NK and NKT-like cells in relation to other immune cells as well as to examine associations between increased susceptibility to infections and NK and NKT-like status in patients with recurrent furunculosis (RF) and healthy controls. Thirty patients with RF and 20 healthy age- and sex-matched volunteers were recruited. Blood samples were examined. Lymphocyte count and cytometric analyses were conducted. For statistical analysis, the Student’s t test, F test, and Brown–Forsythe test were used for comparison between groups of variables. Associations were assessed with Pearson coefficient. Patients with RF had lower lymphocyte count than controls. Additionally, they presented with the following changes in the blood picture: a significant increase in the number of NK cells with a CD3(+)CD16(+)CD56(+) phenotype; a proportional increase in the number and percentage of NKT-like cells with a CD3(+)CD16(+)CD56(+) phenotype; a significant decrease in the number and percentage of T CD3(+) cells. The number of NK cells was strongly positively correlated with the number of CD3 cells (r = 0.6162). The number of NKT cells was strongly positively correlated with CD3 cells (r = 0.6885) and CD3CD8 cells (r = 0.5465). Periodic exacerbations in RF are associated with the development of furuncles, which are a result of many already discovered as well as just being examined mechanisms. One of them is a significant increase in the number and most likely activation of NK and NKT-like cells during the formation of the inflammatory process and furuncles. Springer International Publishing 2017-12-13 2018 /pmc/articles/PMC6061139/ /pubmed/29236128 http://dx.doi.org/10.1007/s00005-017-0500-8 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Nowicka, Danuta Grywalska, Ewelina Fitas, Elżbieta Mielnik, Michał Roliński, Jacek NK and NKT-Like Cells in Patients with Recurrent Furunculosis |
title | NK and NKT-Like Cells in Patients with Recurrent Furunculosis |
title_full | NK and NKT-Like Cells in Patients with Recurrent Furunculosis |
title_fullStr | NK and NKT-Like Cells in Patients with Recurrent Furunculosis |
title_full_unstemmed | NK and NKT-Like Cells in Patients with Recurrent Furunculosis |
title_short | NK and NKT-Like Cells in Patients with Recurrent Furunculosis |
title_sort | nk and nkt-like cells in patients with recurrent furunculosis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061139/ https://www.ncbi.nlm.nih.gov/pubmed/29236128 http://dx.doi.org/10.1007/s00005-017-0500-8 |
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