Cargando…

NK and NKT-Like Cells in Patients with Recurrent Furunculosis

To analyze changes in the number and percentage of NK and NKT-like cells in relation to other immune cells as well as to examine associations between increased susceptibility to infections and NK and NKT-like status in patients with recurrent furunculosis (RF) and healthy controls. Thirty patients w...

Descripción completa

Detalles Bibliográficos
Autores principales: Nowicka, Danuta, Grywalska, Ewelina, Fitas, Elżbieta, Mielnik, Michał, Roliński, Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061139/
https://www.ncbi.nlm.nih.gov/pubmed/29236128
http://dx.doi.org/10.1007/s00005-017-0500-8
_version_ 1783342159569616896
author Nowicka, Danuta
Grywalska, Ewelina
Fitas, Elżbieta
Mielnik, Michał
Roliński, Jacek
author_facet Nowicka, Danuta
Grywalska, Ewelina
Fitas, Elżbieta
Mielnik, Michał
Roliński, Jacek
author_sort Nowicka, Danuta
collection PubMed
description To analyze changes in the number and percentage of NK and NKT-like cells in relation to other immune cells as well as to examine associations between increased susceptibility to infections and NK and NKT-like status in patients with recurrent furunculosis (RF) and healthy controls. Thirty patients with RF and 20 healthy age- and sex-matched volunteers were recruited. Blood samples were examined. Lymphocyte count and cytometric analyses were conducted. For statistical analysis, the Student’s t test, F test, and Brown–Forsythe test were used for comparison between groups of variables. Associations were assessed with Pearson coefficient. Patients with RF had lower lymphocyte count than controls. Additionally, they presented with the following changes in the blood picture: a significant increase in the number of NK cells with a CD3(+)CD16(+)CD56(+) phenotype; a proportional increase in the number and percentage of NKT-like cells with a CD3(+)CD16(+)CD56(+) phenotype; a significant decrease in the number and percentage of T CD3(+) cells. The number of NK cells was strongly positively correlated with the number of CD3 cells (r = 0.6162). The number of NKT cells was strongly positively correlated with CD3 cells (r = 0.6885) and CD3CD8 cells (r = 0.5465). Periodic exacerbations in RF are associated with the development of furuncles, which are a result of many already discovered as well as just being examined mechanisms. One of them is a significant increase in the number and most likely activation of NK and NKT-like cells during the formation of the inflammatory process and furuncles.
format Online
Article
Text
id pubmed-6061139
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Springer International Publishing
record_format MEDLINE/PubMed
spelling pubmed-60611392018-08-09 NK and NKT-Like Cells in Patients with Recurrent Furunculosis Nowicka, Danuta Grywalska, Ewelina Fitas, Elżbieta Mielnik, Michał Roliński, Jacek Arch Immunol Ther Exp (Warsz) Original Article To analyze changes in the number and percentage of NK and NKT-like cells in relation to other immune cells as well as to examine associations between increased susceptibility to infections and NK and NKT-like status in patients with recurrent furunculosis (RF) and healthy controls. Thirty patients with RF and 20 healthy age- and sex-matched volunteers were recruited. Blood samples were examined. Lymphocyte count and cytometric analyses were conducted. For statistical analysis, the Student’s t test, F test, and Brown–Forsythe test were used for comparison between groups of variables. Associations were assessed with Pearson coefficient. Patients with RF had lower lymphocyte count than controls. Additionally, they presented with the following changes in the blood picture: a significant increase in the number of NK cells with a CD3(+)CD16(+)CD56(+) phenotype; a proportional increase in the number and percentage of NKT-like cells with a CD3(+)CD16(+)CD56(+) phenotype; a significant decrease in the number and percentage of T CD3(+) cells. The number of NK cells was strongly positively correlated with the number of CD3 cells (r = 0.6162). The number of NKT cells was strongly positively correlated with CD3 cells (r = 0.6885) and CD3CD8 cells (r = 0.5465). Periodic exacerbations in RF are associated with the development of furuncles, which are a result of many already discovered as well as just being examined mechanisms. One of them is a significant increase in the number and most likely activation of NK and NKT-like cells during the formation of the inflammatory process and furuncles. Springer International Publishing 2017-12-13 2018 /pmc/articles/PMC6061139/ /pubmed/29236128 http://dx.doi.org/10.1007/s00005-017-0500-8 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Nowicka, Danuta
Grywalska, Ewelina
Fitas, Elżbieta
Mielnik, Michał
Roliński, Jacek
NK and NKT-Like Cells in Patients with Recurrent Furunculosis
title NK and NKT-Like Cells in Patients with Recurrent Furunculosis
title_full NK and NKT-Like Cells in Patients with Recurrent Furunculosis
title_fullStr NK and NKT-Like Cells in Patients with Recurrent Furunculosis
title_full_unstemmed NK and NKT-Like Cells in Patients with Recurrent Furunculosis
title_short NK and NKT-Like Cells in Patients with Recurrent Furunculosis
title_sort nk and nkt-like cells in patients with recurrent furunculosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061139/
https://www.ncbi.nlm.nih.gov/pubmed/29236128
http://dx.doi.org/10.1007/s00005-017-0500-8
work_keys_str_mv AT nowickadanuta nkandnktlikecellsinpatientswithrecurrentfurunculosis
AT grywalskaewelina nkandnktlikecellsinpatientswithrecurrentfurunculosis
AT fitaselzbieta nkandnktlikecellsinpatientswithrecurrentfurunculosis
AT mielnikmichał nkandnktlikecellsinpatientswithrecurrentfurunculosis
AT rolinskijacek nkandnktlikecellsinpatientswithrecurrentfurunculosis