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The Significance of the Intestinal Microbiome for Vaccinology: From Correlations to Therapeutic Applications

Despite unprecedented advances in understanding the intestinal microbiome, its potential to improve fields such as vaccinology has yet to be realized. This review briefly outlines the immunologic potential of the intestinal microbiome for vaccinology and highlights areas where the microbiome holds s...

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Detalles Bibliográficos
Autor principal: Harris, Vanessa C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061423/
https://www.ncbi.nlm.nih.gov/pubmed/29943376
http://dx.doi.org/10.1007/s40265-018-0941-3
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author Harris, Vanessa C.
author_facet Harris, Vanessa C.
author_sort Harris, Vanessa C.
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description Despite unprecedented advances in understanding the intestinal microbiome, its potential to improve fields such as vaccinology has yet to be realized. This review briefly outlines the immunologic potential of the intestinal microbiome for vaccinology and highlights areas where the microbiome holds specific promise in vaccinology. Oral rotavirus vaccine effectiveness in low-income countries is used as a case study to describe how the intestinal microbiome may be employed to improve a vaccine’s immunogenicity. A top-down, evidence-based approach is proposed to identify effective microbiota-based applications for vaccine improvement. Applying evidence from field studies in pertinent populations that correlate microbiome composition with vaccine effectiveness to appropriate experimental platforms will lead to the identification of safe, vaccine-supporting microbiota targets that are relevant to populations in need of improvement in vaccine-induced immunity.
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spelling pubmed-60614232018-08-09 The Significance of the Intestinal Microbiome for Vaccinology: From Correlations to Therapeutic Applications Harris, Vanessa C. Drugs Current Opinion Despite unprecedented advances in understanding the intestinal microbiome, its potential to improve fields such as vaccinology has yet to be realized. This review briefly outlines the immunologic potential of the intestinal microbiome for vaccinology and highlights areas where the microbiome holds specific promise in vaccinology. Oral rotavirus vaccine effectiveness in low-income countries is used as a case study to describe how the intestinal microbiome may be employed to improve a vaccine’s immunogenicity. A top-down, evidence-based approach is proposed to identify effective microbiota-based applications for vaccine improvement. Applying evidence from field studies in pertinent populations that correlate microbiome composition with vaccine effectiveness to appropriate experimental platforms will lead to the identification of safe, vaccine-supporting microbiota targets that are relevant to populations in need of improvement in vaccine-induced immunity. Springer International Publishing 2018-06-26 2018 /pmc/articles/PMC6061423/ /pubmed/29943376 http://dx.doi.org/10.1007/s40265-018-0941-3 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Current Opinion
Harris, Vanessa C.
The Significance of the Intestinal Microbiome for Vaccinology: From Correlations to Therapeutic Applications
title The Significance of the Intestinal Microbiome for Vaccinology: From Correlations to Therapeutic Applications
title_full The Significance of the Intestinal Microbiome for Vaccinology: From Correlations to Therapeutic Applications
title_fullStr The Significance of the Intestinal Microbiome for Vaccinology: From Correlations to Therapeutic Applications
title_full_unstemmed The Significance of the Intestinal Microbiome for Vaccinology: From Correlations to Therapeutic Applications
title_short The Significance of the Intestinal Microbiome for Vaccinology: From Correlations to Therapeutic Applications
title_sort significance of the intestinal microbiome for vaccinology: from correlations to therapeutic applications
topic Current Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061423/
https://www.ncbi.nlm.nih.gov/pubmed/29943376
http://dx.doi.org/10.1007/s40265-018-0941-3
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