Cross-Site Reliability of Human Induced Pluripotent stem cell-derived Cardiomyocyte Based Safety Assays Using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study

Recent in vitro cardiac safety studies demonstrate the ability of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to detect electrophysiologic effects of drugs. However, variability contributed by unique approaches, procedures, cell lines, and reagents across laboratories make...

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Detalles Bibliográficos
Autores principales: Millard, Daniel, Dang, Qianyu, Shi, Hong, Zhang, Xiaou, Strock, Chris, Kraushaar, Udo, Zeng, Haoyu, Levesque, Paul, Lu, Hua-Rong, Guillon, Jean-Michel, Wu, Joseph C, Li, Yingxin, Luerman, Greg, Anson, Blake, Guo, Liang, Clements, Mike, Abassi, Yama A, Ross, James, Pierson, Jennifer, Gintant, Gary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
RELIABILITY OF HUMAN iPSC-DERIVED CARDIOMYOCYTES FOR SAFETY ASSAYS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061700/
https://www.ncbi.nlm.nih.gov/pubmed/29718449
http://dx.doi.org/10.1093/toxsci/kfy110

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