Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice

Mitochondrial DNA (mtDNA) mutations become more prevalent with age and are postulated to contribute to the ageing process. Point mutations of mtDNA have been suggested to originate from two main sources, i.e. replicative errors and oxidative damage, but the contribution of each of these processes is...

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Detalles Bibliográficos
Autores principales: Kauppila, Johanna H K, Bonekamp, Nina A, Mourier, Arnaud, Isokallio, Marita A, Just, Alexandra, Kauppila, Timo E S, Stewart, James B, Larsson, Nils-Göran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061787/
https://www.ncbi.nlm.nih.gov/pubmed/29860357
http://dx.doi.org/10.1093/nar/gky456

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