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Hg(II) binds to C–T mismatches with high affinity

Binding reactions of Hg(II) and Ag(I) to pyrimidine-pyrimidine mismatches in duplex DNA were characterized using fluorescent nucleobase analogs, thermal denaturation and (1)H NMR. Unlike Ag(I), Hg(II) exhibited stoichiometric, site-specific binding of C–T mismatches. The on- and off-rates of Hg(II)...

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Detalles Bibliográficos
Autores principales:	Schmidt, Olivia P, Benz, Andrea S, Mata, Guillaume, Luedtke, Nathan W
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061796/ https://www.ncbi.nlm.nih.gov/pubmed/29901748 http://dx.doi.org/10.1093/nar/gky499

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