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Circular permutation profiling by deep sequencing libraries created using transposon mutagenesis

Deep mutational scanning has been used to create high-resolution DNA sequence maps that illustrate the functional consequences of large numbers of point mutations. However, this approach has not yet been applied to libraries of genes created by random circular permutation, an engineering strategy th...

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Detalles Bibliográficos
Autores principales: Atkinson, Joshua T, Jones, Alicia M, Zhou, Quan, Silberg, Jonathan J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061844/
https://www.ncbi.nlm.nih.gov/pubmed/29912470
http://dx.doi.org/10.1093/nar/gky255

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