MIRA: an R package for DNA methylation-based inference of regulatory activity

SUMMARY: DNA methylation contains information about the regulatory state of the cell. MIRA aggregates genome-scale DNA methylation data into a DNA methylation profile for a given region set with shared biological annotation. Using this profile, MIRA infers and scores the collective regulatory activi...

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Detalles Bibliográficos
Autores principales: Lawson, John T, Tomazou, Eleni M, Bock, Christoph, Sheffield, Nathan C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Applications Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061852/
https://www.ncbi.nlm.nih.gov/pubmed/29506020
http://dx.doi.org/10.1093/bioinformatics/bty083
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author Lawson, John T
Tomazou, Eleni M
Bock, Christoph
Sheffield, Nathan C
author_facet Lawson, John T
Tomazou, Eleni M
Bock, Christoph
Sheffield, Nathan C
author_sort Lawson, John T
collection PubMed
description SUMMARY: DNA methylation contains information about the regulatory state of the cell. MIRA aggregates genome-scale DNA methylation data into a DNA methylation profile for a given region set with shared biological annotation. Using this profile, MIRA infers and scores the collective regulatory activity for the region set. MIRA facilitates regulatory analysis in situations where classical regulatory assays would be difficult and allows public sources of region sets to be leveraged for novel insight into the regulatory state of DNA methylation datasets. AVAILABILITY AND IMPLEMENTATION: http://bioconductor.org/packages/MIRA.
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spelling pubmed-60618522018-08-07 MIRA: an R package for DNA methylation-based inference of regulatory activity Lawson, John T Tomazou, Eleni M Bock, Christoph Sheffield, Nathan C Bioinformatics Applications Notes SUMMARY: DNA methylation contains information about the regulatory state of the cell. MIRA aggregates genome-scale DNA methylation data into a DNA methylation profile for a given region set with shared biological annotation. Using this profile, MIRA infers and scores the collective regulatory activity for the region set. MIRA facilitates regulatory analysis in situations where classical regulatory assays would be difficult and allows public sources of region sets to be leveraged for novel insight into the regulatory state of DNA methylation datasets. AVAILABILITY AND IMPLEMENTATION: http://bioconductor.org/packages/MIRA. Oxford University Press 2018-08-01 2018-03-01 /pmc/articles/PMC6061852/ /pubmed/29506020 http://dx.doi.org/10.1093/bioinformatics/bty083 Text en © The Author(s) 2018. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Applications Notes
Lawson, John T
Tomazou, Eleni M
Bock, Christoph
Sheffield, Nathan C
MIRA: an R package for DNA methylation-based inference of regulatory activity
title MIRA: an R package for DNA methylation-based inference of regulatory activity
title_full MIRA: an R package for DNA methylation-based inference of regulatory activity
title_fullStr MIRA: an R package for DNA methylation-based inference of regulatory activity
title_full_unstemmed MIRA: an R package for DNA methylation-based inference of regulatory activity
title_short MIRA: an R package for DNA methylation-based inference of regulatory activity
title_sort mira: an r package for dna methylation-based inference of regulatory activity
topic Applications Notes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061852/
https://www.ncbi.nlm.nih.gov/pubmed/29506020
http://dx.doi.org/10.1093/bioinformatics/bty083
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