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Evaluating the potential role of pleiotropy in Mendelian randomization studies

Pleiotropy, the phenomenon of a single genetic variant influencing multiple traits, is likely widespread in the human genome. If pleiotropy arises because the single nucleotide polymorphism (SNP) influences one trait, which in turn influences another (‘vertical pleiotropy’), then Mendelian randomiza...

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Detalles Bibliográficos
Autores principales:	Hemani, Gibran, Bowden, Jack, Davey Smith, George
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Invited Reviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061876/ https://www.ncbi.nlm.nih.gov/pubmed/29771313 http://dx.doi.org/10.1093/hmg/ddy163

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