Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration

Hypoxia-inducible factor 1 (HIF-1) is a master transcriptional regulator in response to hypoxia and its transcriptional activity is crucial for cancer cell mobility. Here we present evidence for a novel epigenetic mechanism that regulates HIF-1 transcriptional activity and HIF-1-dependent migration...

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Detalles Bibliográficos
Autores principales: Bao, Lei, Chen, Yan, Lai, Hsien-Tsung, Wu, Shwu-Yuan, Wang, Jennifer E, Hatanpaa, Kimmo J, Raisanen, Jack M, Fontenot, Miles, Lega, Bradley, Chiang, Cheng-Ming, Semenza, Gregg L, Wang, Yingfei, Luo, Weibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061882/
https://www.ncbi.nlm.nih.gov/pubmed/29860315
http://dx.doi.org/10.1093/nar/gky449

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