5-Formylcytosine mediated DNA–protein cross-links block DNA replication and induce mutations in human cells

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5-Formylcytosine (5fC) is an epigenetic DNA modification introduced via TET protein-mediated oxidation of 5-methyl-dC. We recently reported that 5fC form reversible DNA–protein conjugates (DPCs) with histone proteins in living cells (Ji et al. (2017) Angew. Chem. Int. Ed., 56:14130–14134). We now ex...

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Detalles Bibliográficos
Autores principales: Ji, Shaofei, Fu, Iwen, Naldiga, Spandana, Shao, Hongzhao, Basu, Ashis K, Broyde, Suse, Tretyakova, Natalia Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061883/
https://www.ncbi.nlm.nih.gov/pubmed/29905846
http://dx.doi.org/10.1093/nar/gky444
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