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Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study
High-frequency ultrasound imaging can provide exquisite visualizations of tissue to guide minimally invasive procedures. Here, we demonstrate that an all-optical ultrasound transducer, through which light guided by optical fibers is used to generate and receive ultrasound, is suitable for real-time...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062020/ https://www.ncbi.nlm.nih.gov/pubmed/30167220 http://dx.doi.org/10.1038/lsa.2017.103 |
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author | Finlay, Malcolm C Mosse, Charles A Colchester, Richard J Noimark, Sacha Zhang, Edward Z Ourselin, Sebastien Beard, Paul C Schilling, Richard J Parkin, Ivan P Papakonstantinou, Ioannis Desjardins, Adrien E |
author_facet | Finlay, Malcolm C Mosse, Charles A Colchester, Richard J Noimark, Sacha Zhang, Edward Z Ourselin, Sebastien Beard, Paul C Schilling, Richard J Parkin, Ivan P Papakonstantinou, Ioannis Desjardins, Adrien E |
author_sort | Finlay, Malcolm C |
collection | PubMed |
description | High-frequency ultrasound imaging can provide exquisite visualizations of tissue to guide minimally invasive procedures. Here, we demonstrate that an all-optical ultrasound transducer, through which light guided by optical fibers is used to generate and receive ultrasound, is suitable for real-time invasive medical imaging in vivo. Broad-bandwidth ultrasound generation was achieved through the photoacoustic excitation of a multiwalled carbon nanotube-polydimethylsiloxane composite coating on the distal end of a 300-μm multi-mode optical fiber by a pulsed laser. The interrogation of a high-finesse Fabry–Pérot cavity on a single-mode optical fiber by a wavelength-tunable continuous-wave laser was applied for ultrasound reception. This transducer was integrated within a custom inner transseptal needle (diameter 1.08 mm; length 78 cm) that included a metallic septum to acoustically isolate the two optical fibers. The use of this needle within the beating heart of a pig provided unprecedented real-time views (50 Hz scan rate) of cardiac tissue (depth: 2.5 cm; axial resolution: 64 μm) and revealed the critical anatomical structures required to safely perform a transseptal crossing: the right and left atrial walls, the right atrial appendage, and the limbus fossae ovalis. This new paradigm will allow ultrasound imaging to be integrated into a broad range of minimally invasive devices in different clinical contexts. |
format | Online Article Text |
id | pubmed-6062020 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-60620202018-08-30 Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study Finlay, Malcolm C Mosse, Charles A Colchester, Richard J Noimark, Sacha Zhang, Edward Z Ourselin, Sebastien Beard, Paul C Schilling, Richard J Parkin, Ivan P Papakonstantinou, Ioannis Desjardins, Adrien E Light Sci Appl Original Article High-frequency ultrasound imaging can provide exquisite visualizations of tissue to guide minimally invasive procedures. Here, we demonstrate that an all-optical ultrasound transducer, through which light guided by optical fibers is used to generate and receive ultrasound, is suitable for real-time invasive medical imaging in vivo. Broad-bandwidth ultrasound generation was achieved through the photoacoustic excitation of a multiwalled carbon nanotube-polydimethylsiloxane composite coating on the distal end of a 300-μm multi-mode optical fiber by a pulsed laser. The interrogation of a high-finesse Fabry–Pérot cavity on a single-mode optical fiber by a wavelength-tunable continuous-wave laser was applied for ultrasound reception. This transducer was integrated within a custom inner transseptal needle (diameter 1.08 mm; length 78 cm) that included a metallic septum to acoustically isolate the two optical fibers. The use of this needle within the beating heart of a pig provided unprecedented real-time views (50 Hz scan rate) of cardiac tissue (depth: 2.5 cm; axial resolution: 64 μm) and revealed the critical anatomical structures required to safely perform a transseptal crossing: the right and left atrial walls, the right atrial appendage, and the limbus fossae ovalis. This new paradigm will allow ultrasound imaging to be integrated into a broad range of minimally invasive devices in different clinical contexts. Nature Publishing Group 2017-12-01 /pmc/articles/PMC6062020/ /pubmed/30167220 http://dx.doi.org/10.1038/lsa.2017.103 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Original Article Finlay, Malcolm C Mosse, Charles A Colchester, Richard J Noimark, Sacha Zhang, Edward Z Ourselin, Sebastien Beard, Paul C Schilling, Richard J Parkin, Ivan P Papakonstantinou, Ioannis Desjardins, Adrien E Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study |
title | Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study |
title_full | Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study |
title_fullStr | Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study |
title_full_unstemmed | Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study |
title_short | Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study |
title_sort | through-needle all-optical ultrasound imaging in vivo: a preclinical swine study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062020/ https://www.ncbi.nlm.nih.gov/pubmed/30167220 http://dx.doi.org/10.1038/lsa.2017.103 |
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