Autophagic cell death associated to Sorafenib in renal cell carcinoma is mediated through Akt inhibition in an ERK1/2 independent fashion

OBJECTIVES: To fully clarify the role of Mitogen Activated Protein Kinase in the therapeutic response to Sorafenib in Renal Cell Carcinoma as well as the cell death mechanism associated to this kinase inhibitor, we have evaluated the implication of several Mitogen Activated Protein Kinases in Renal...

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Detalles Bibliográficos
Autores principales: Serrano-Oviedo, Leticia, Ortega-Muelas, Marta, García-Cano, Jesús, Valero, María Ll., Cimas, Francisco J., Pascual-Serra, Raquel, Fernandez-Aroca, Diego M., Roche, Olga, Ruiz-Hidalgo, María J., Belandia, Borja, Giménez-Bachs, José M., Salinas, Antonio S., Sanchez-Prieto, Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062059/
https://www.ncbi.nlm.nih.gov/pubmed/30048489
http://dx.doi.org/10.1371/journal.pone.0200878

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