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Skills attained by infants with congenital Zika syndrome: Pilot data from Brazil

The recent Zika outbreak and its link to microcephaly and other birth defects in infants exposed in utero have garnered widespread international attention. Based on the severity of birth defects the extent of impairment in these infants is expected to be profound; however, virtually nothing is known...

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Autores principales: Wheeler, Anne C., Ventura, Camila V., Ridenour, Ty, Toth, Danielle, Nobrega, Lucélia Lima, Silva de Souza Dantas, Lana Claudia, Rocha, Camilla, Bailey, Donald B., Ventura, Liana O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062124/
https://www.ncbi.nlm.nih.gov/pubmed/30048541
http://dx.doi.org/10.1371/journal.pone.0201495
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author Wheeler, Anne C.
Ventura, Camila V.
Ridenour, Ty
Toth, Danielle
Nobrega, Lucélia Lima
Silva de Souza Dantas, Lana Claudia
Rocha, Camilla
Bailey, Donald B.
Ventura, Liana O.
author_facet Wheeler, Anne C.
Ventura, Camila V.
Ridenour, Ty
Toth, Danielle
Nobrega, Lucélia Lima
Silva de Souza Dantas, Lana Claudia
Rocha, Camilla
Bailey, Donald B.
Ventura, Liana O.
author_sort Wheeler, Anne C.
collection PubMed
description The recent Zika outbreak and its link to microcephaly and other birth defects in infants exposed in utero have garnered widespread international attention. Based on the severity of birth defects the extent of impairment in these infants is expected to be profound; however, virtually nothing is known regarding the developmental and behavioral sequela of congenital Zika syndrome. This pilot study collected parent-reported patterns of development and sleep in 47 infants with confirmed congenital Zika syndrome who are being followed for clinical services at the Altino Ventura Foundation (FAV) in Recife, Brazil. With assistance from clinicians at FAV, caregivers completed Brazilian Portuguese versions of the Ages and Stages Questionnaire, 3(rd) edition (ASQ-3) and the Brief Infant Sleep Questionnaire (BISQ). All infants were between 13–22 months of age at the time of the assessment. At 16 months of age, none of the children displayed age appropriate developmental skills. Most (~ 75%) mastered some communication and gross motor skills at around a 6–8-month level. Communication and gross motor skills were relative strengths for the sample, while problem-solving and fine motor skills were relative weaknesses. Sleep was noted to be a problem for around 18% of the sample. In utero exposure to the Zika virus will have lifelong consequences for affected children and their families. Understanding the developmental and behavioral trajectories of affected infants will help identify appropriate family supports to improve quality of life.
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spelling pubmed-60621242018-08-03 Skills attained by infants with congenital Zika syndrome: Pilot data from Brazil Wheeler, Anne C. Ventura, Camila V. Ridenour, Ty Toth, Danielle Nobrega, Lucélia Lima Silva de Souza Dantas, Lana Claudia Rocha, Camilla Bailey, Donald B. Ventura, Liana O. PLoS One Research Article The recent Zika outbreak and its link to microcephaly and other birth defects in infants exposed in utero have garnered widespread international attention. Based on the severity of birth defects the extent of impairment in these infants is expected to be profound; however, virtually nothing is known regarding the developmental and behavioral sequela of congenital Zika syndrome. This pilot study collected parent-reported patterns of development and sleep in 47 infants with confirmed congenital Zika syndrome who are being followed for clinical services at the Altino Ventura Foundation (FAV) in Recife, Brazil. With assistance from clinicians at FAV, caregivers completed Brazilian Portuguese versions of the Ages and Stages Questionnaire, 3(rd) edition (ASQ-3) and the Brief Infant Sleep Questionnaire (BISQ). All infants were between 13–22 months of age at the time of the assessment. At 16 months of age, none of the children displayed age appropriate developmental skills. Most (~ 75%) mastered some communication and gross motor skills at around a 6–8-month level. Communication and gross motor skills were relative strengths for the sample, while problem-solving and fine motor skills were relative weaknesses. Sleep was noted to be a problem for around 18% of the sample. In utero exposure to the Zika virus will have lifelong consequences for affected children and their families. Understanding the developmental and behavioral trajectories of affected infants will help identify appropriate family supports to improve quality of life. Public Library of Science 2018-07-26 /pmc/articles/PMC6062124/ /pubmed/30048541 http://dx.doi.org/10.1371/journal.pone.0201495 Text en © 2018 Wheeler et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Wheeler, Anne C.
Ventura, Camila V.
Ridenour, Ty
Toth, Danielle
Nobrega, Lucélia Lima
Silva de Souza Dantas, Lana Claudia
Rocha, Camilla
Bailey, Donald B.
Ventura, Liana O.
Skills attained by infants with congenital Zika syndrome: Pilot data from Brazil
title Skills attained by infants with congenital Zika syndrome: Pilot data from Brazil
title_full Skills attained by infants with congenital Zika syndrome: Pilot data from Brazil
title_fullStr Skills attained by infants with congenital Zika syndrome: Pilot data from Brazil
title_full_unstemmed Skills attained by infants with congenital Zika syndrome: Pilot data from Brazil
title_short Skills attained by infants with congenital Zika syndrome: Pilot data from Brazil
title_sort skills attained by infants with congenital zika syndrome: pilot data from brazil
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062124/
https://www.ncbi.nlm.nih.gov/pubmed/30048541
http://dx.doi.org/10.1371/journal.pone.0201495
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