Cargando…

Systems toxicology meta-analysis of in vitro assessment studies: biological impact of a candidate modified-risk tobacco product aerosol compared with cigarette smoke on human organotypic cultures of the aerodigestive tract

Systems biology combines comprehensive molecular analyses with quantitative modeling to understand the characteristics of a biological system as a whole. Leveraging a similar approach, systems toxicology aims to decipher complex biological responses following exposures. This work reports a systems t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Iskandar, A. R., Titz, B., Sewer, A., Leroy, P., Schneider, T., Zanetti, F., Mathis, C., Elamin, A., Frentzel, S., Schlage, W. K., Martin, F., Ivanov, N. V., Peitsch, M. C., Hoeng, J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2017
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062142/ https://www.ncbi.nlm.nih.gov/pubmed/30090531 http://dx.doi.org/10.1039/c7tx00047b

Ejemplares similares

Comparative effects of a candidate modified-risk tobacco product Aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach
por: Iskandar, Anita R., et al.
Publicado: (2017)

In vitro systems toxicology approach to investigate the effects of repeated cigarette smoke exposure on human buccal and gingival organotypic epithelial tissue cultures
por: Schlage, Walter K., et al.
Publicado: (2014)

A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems toxicology assessment
por: Iskandar, Anita R., et al.
Publicado: (2019)

Multi-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke
por: Titz, Bjoern, et al.
Publicado: (2020)

Impact Assessment of Cigarette Smoke Exposure on Organotypic Bronchial Epithelial Tissue Cultures: A Comparison of Mono-Culture and Coculture Model Containing Fibroblasts
por: Iskandar, Anita R., et al.
Publicado: (2015)

A meta-analysis of microRNAs expressed in human aerodigestive epithelial cultures and their role as potential biomarkers of exposure response to nicotine-containing products
por: Sewer, Alain, et al.
Publicado: (2020)

Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke
por: Kuehn, Diana, et al.
Publicado: (2015)

Systems toxicology approaches enable mechanistic comparison of spontaneous and cigarette smoke-related lung tumor development in the A/J mouse model
por: Luettich, Karsta, et al.
Publicado: (2014)

Proteomics for systems toxicology
por: Titz, Bjoern, et al.
Publicado: (2014)

A framework for in vitro systems toxicology assessment of e-liquids
por: Iskandar, Anita R., et al.
Publicado: (2016)

Respiratory Effects of Exposure to Aerosol From the Candidate Modified-Risk Tobacco Product THS 2.2 in an 18-Month Systems Toxicology Study With A/J Mice
por: Titz, Bjoern, et al.
Publicado: (2020)

Characterization of the Vitrocell® 24/48 in vitro aerosol exposure system using mainstream cigarette smoke
por: Majeed, Shoaib, et al.
Publicado: (2014)

An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe(−/−) Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes
por: Phillips, Blaine, et al.
Publicado: (2016)

An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe(−/−) Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes
por: Phillips, Blaine, et al.
Publicado: (2016)

Effects of Cigarette Smoke, Cessation, and Switching to Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism in C57BL/6 and Apoe(−/−) Mice—An Integrative Systems Toxicology Analysis
por: Titz, Bjoern, et al.
Publicado: (2016)

Systems Approaches Evaluating the Perturbation of Xenobiotic Metabolism in Response to Cigarette Smoke Exposure in Nasal and Bronchial Tissues
por: Iskandar, Anita R., et al.
Publicado: (2013)

Systems toxicology study reveals reduced impact of heated tobacco product aerosol extract relative to cigarette smoke on premature aging and exacerbation effects in aged aortic cells in vitro
por: Poussin, Carine, et al.
Publicado: (2021)

A 6-month inhalation toxicology study in Apoe(−/−) mice demonstrates substantially lower effects of e-vapor aerosol compared with cigarette smoke in the respiratory tract
por: Wong, Ee Tsin, et al.
Publicado: (2021)

Comparison of monoamine oxidase inhibition by cigarettes and modified risk tobacco products
por: van der Toorn, Marco, et al.
Publicado: (2019)

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)
por: Marescotti, Diego, et al.
Publicado: (2016)

Comparing the preclinical risk profile of inhalable candidate and potential candidate modified risk tobacco products: A bridging use case
por: Schlage, Walter K., et al.
Publicado: (2020)

The Apoe(−/−) mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction
por: Lo Sasso, Giuseppe, et al.
Publicado: (2016)

A Systems Biology Approach Reveals the Dose- and Time-Dependent Effect of Primary Human Airway Epithelium Tissue Culture After Exposure to Cigarette Smoke In Vitro
por: Mathis, Carole, et al.
Publicado: (2015)

Impact of whole‐body versus nose‐only inhalation exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2‐month cigarette smoke exposure study in the ApoE(−/−) mouse model
por: Kogel, Ulrike, et al.
Publicado: (2021)

Proteomics and Lipidomics in Inflammatory Bowel Disease Research: From Mechanistic Insights to Biomarker Identification
por: Titz, Bjoern, et al.
Publicado: (2018)

Comprehensive systems biology analysis of a 7-month cigarette smoke inhalation study in C57BL/6 mice
por: Ansari, Sam, et al.
Publicado: (2016)

Reduced Chronic Toxicity and Carcinogenicity in A/J Mice in Response to Life-Time Exposure to Aerosol From a Heated Tobacco Product Compared With Cigarette Smoke
por: Wong, Ee Tsin, et al.
Publicado: (2020)

Impact of 6-Month Exposure to Aerosols From Potential Modified Risk Tobacco Products Relative to Cigarette Smoke on the Rodent Gastrointestinal Tract
por: Battey, James N. D., et al.
Publicado: (2021)

The reduction of DSS-induced colitis severity in mice exposed to cigarette smoke is linked to immune modulation and microbial shifts
por: Lo Sasso, Giuseppe, et al.
Publicado: (2020)

E-vapor aerosols do not compromise bone integrity relative to cigarette smoke after 6-month inhalation in an ApoE(–/–) mouse model
por: Reumann, Marie K., et al.
Publicado: (2020)

Assessment of network perturbation amplitudes by applying high-throughput data to causal biological networks
por: Martin, Florian, et al.
Publicado: (2012)

Assessment of inhalation toxicity of cigarette smoke and aerosols from flavor mixtures: 5‐week study in A/J mice
por: Wong, Ee Tsin, et al.
Publicado: (2022)

Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains
por: Cabanski, Maciej, et al.
Publicado: (2015)

Oral Absorption across Organotypic Culture Models of the Human Buccal Epithelium after E-cigarette Aerosol Exposure
por: Miyauchi, Masato, et al.
Publicado: (2022)

Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models
por: Martin, Florian, et al.
Publicado: (2014)

Pulmonary Delivery of Aerosolized Chloroquine and Hydroxychloroquine to Treat COVID-19: In Vitro Experimentation to Human Dosing Predictions
por: Kolli, Aditya R., et al.
Publicado: (2022)

GladiaTOX: GLobal Assessment of Dose-IndicAtor in TOXicology
por: Belcastro, Vincenzo, et al.
Publicado: (2019)

Organotypic Rat Testicular Organoids for the Study of Testicular Maturation and Toxicology
por: Sakib, Sadman, et al.
Publicado: (2022)

Systems Toxicology Approach for Assessing Developmental Neurotoxicity in Larval Zebrafish
por: Li, Roman A., et al.
Publicado: (2021)

Lung transcriptomic clock predicts premature aging in cigarette smoke-exposed mice
por: Choukrallah, Mohamed-Amin, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_og6p16jeplokavc7ps938c0112