Thymic tuft cells promote an IL4-enriched medulla and shape thymocyte development

The thymus is responsible for generating a diverse yet self-tolerant T cell pool (1). While the thymic medulla is largely composed of developing and mature AIRE(+) epithelial cells, recent evidence suggests far greater heterogeneity amongst medullary thymic epithelial cells than previously appreciat...

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Detalles Bibliográficos
Autores principales: Miller, Corey N., Proekt, Irina, von Moltke, Jakob, Wells, Kristen L., Rajpurkar, Aparna R., Wang, Haiguang, Rattay, Kristin, Khan, Imran S., Metzger, Todd C., Pollack, Joshua L., Fries, Adam C., Lwin, Wint W., Wigton, Eric J., Parent, Audrey V., Kyewski, Bruno, Erle, David J., Hogquist, Kristin A., Steinmetz, Lars M., Locksley, Richard M., Anderson, Mark S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062473/
https://www.ncbi.nlm.nih.gov/pubmed/30022164
http://dx.doi.org/10.1038/s41586-018-0345-2

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