Mediation analysis reveals common mechanisms of RUNX1 point mutations and RUNX1/RUNX1T1 fusions influencing survival of patients with acute myeloid leukemia

Alterations of RUNX1 in acute myeloid leukemia (AML) are associated with either a more favorable outcome in the case of the RUNX1/RUNX1T1 fusion or unfavorable prognosis in the case of point mutations. In this project we aimed to identify genes responsible for the observed differences in outcome tha...

Descripción completa

Detalles Bibliográficos
Autores principales: Hornung, Roman, Jurinovic, Vindi, Batcha, Aarif M. N., Bamopoulos, Stefanos A., Rothenberg-Thurley, Maja, Amler, Susanne, Sauerland, Maria Cristina, Berdel, Wolfgang E., Wörmann, Bernhard J., Bohlander, Stefan K., Braess, Jan, Hiddemann, Wolfgang, Lehmann, Sören, Mareschal, Sylvain, Spiekermann, Karsten, Metzeler, Klaus H., Herold, Tobias, Boulesteix, Anne-Laure
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062501/
https://www.ncbi.nlm.nih.gov/pubmed/30050054
http://dx.doi.org/10.1038/s41598-018-29593-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062501/
https://www.ncbi.nlm.nih.gov/pubmed/30050054
http://dx.doi.org/10.1038/s41598-018-29593-2

Ejemplares similares