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Intracellular oligonucleotide delivery using the cell penetrating peptide Xentry

The current study investigated the use of two cationic peptides, Xentry-KALA (XK) and Xentry-Protamine (XP), for intracellular delivery of Connexin43 antisense oligonucleotides (Cx43AsODN). The charge and size of Cx43AsODN:XK and Cx43AsODN:XP complexes was determined by Zetasizer analysis. The earli...

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Detalles Bibliográficos
Autores principales: Coutinho, Frazer P., Green, Colin R., Rupenthal, Ilva D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062516/
https://www.ncbi.nlm.nih.gov/pubmed/30050146
http://dx.doi.org/10.1038/s41598-018-29556-7