Identification of an I(Na)-dependent and I(to)-mediated proarrhythmic mechanism in cardiomyocytes derived from pluripotent stem cells of a Brugada syndrome patient

Brugada syndrome (BrS) is an inherited cardiac arrhythmia commonly associated with SCN5A mutations, yet its ionic mechanisms remain unclear due to a lack of cellular models. Here, we used human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) from a BrS patient (BrS1) to evaluate the...

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Detalles Bibliográficos
Autores principales: Ma, Dongrui, Liu, Zhenfeng, Loh, Li Jun, Zhao, Yongxing, Li, Guang, Liew, Reginald, Islam, Omedul, Wu, Jianjun, Chung, Ying Ying, Teo, Wee Siong, Ching, Chi Keong, Tan, Boon Yew, Chong, Daniel, Ho, Kah Leng, Lim, Paul, Yong, Rita Yu Yin, Panama, Brian K., Kaplan, Aaron D., Bett, Glenna C. L., Ware, James, Bezzina, Connie R., Verkerk, Arie O., Cook, Stuart A., Rasmusson, Randall L., Wei, Heming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062539/
https://www.ncbi.nlm.nih.gov/pubmed/30050137
http://dx.doi.org/10.1038/s41598-018-29574-5

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