Co-inhibition of mTORC1, HDAC and ESR1α retards the growth of triple-negative breast cancer and suppresses cancer stem cells

Triple-negative breast cancer (TNBC) is the most refractory subtype of breast cancer. It causes the majority of breast cancer-related deaths, which has been largely associated with the plasticity of tumor cells and persistence of cancer stem cells (CSCs). Conventional chemotherapeutics enrich CSCs a...

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Detalles Bibliográficos
Autores principales: Sulaiman, Andrew, McGarry, Sarah, Lam, Ka Mien, El-Sahli, Sara, Chambers, Jason, Kaczmarek, Shelby, Li, Li, Addison, Christina, Dimitroulakos, Jim, Arnaout, Angel, Nessim, Carolyn, Yao, Zemin, Ji, Guang, Song, Haiyan, Liu, Sheng, Xie, Ying, Gadde, Suresh, Li, Xuguang, Wang, Lisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062597/
https://www.ncbi.nlm.nih.gov/pubmed/30050079
http://dx.doi.org/10.1038/s41419-018-0811-7

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