Infection of novel reassortant H1N2 and H3N2 swine influenza A viruses in the guinea pig model

Novel H1N2 and H3N2 swine influenza A viruses (IAVs) were identified in commercial farms in Chile. These viruses contained H1, H3 and N2 sequences, genetically divergent from IAVs described worldwide, associated with pandemic internal genes. Guinea pigs were used as human surrogate to evaluate the i...

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Autores principales: Tapia, Rodrigo, García, Victoria, Mena, Juan, Bucarey, Sergio, Medina, Rafael A., Neira, Víctor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062863/
https://www.ncbi.nlm.nih.gov/pubmed/30053826
http://dx.doi.org/10.1186/s13567-018-0572-4
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author Tapia, Rodrigo
García, Victoria
Mena, Juan
Bucarey, Sergio
Medina, Rafael A.
Neira, Víctor
author_facet Tapia, Rodrigo
García, Victoria
Mena, Juan
Bucarey, Sergio
Medina, Rafael A.
Neira, Víctor
author_sort Tapia, Rodrigo
collection PubMed
description Novel H1N2 and H3N2 swine influenza A viruses (IAVs) were identified in commercial farms in Chile. These viruses contained H1, H3 and N2 sequences, genetically divergent from IAVs described worldwide, associated with pandemic internal genes. Guinea pigs were used as human surrogate to evaluate the infection dynamics of these reassortant viruses, compared with a pandemic H1N1 virus. All viruses replicated and were shed in the upper respiratory tract without prior adaptation although H1N2 viruses showed the highest shedding titers. This could have public health importance, emphasizing the need to carry out further studies to evaluate the zoonotic potential of these viruses. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13567-018-0572-4) contains supplementary material, which is available to authorized users.
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spelling pubmed-60628632018-07-31 Infection of novel reassortant H1N2 and H3N2 swine influenza A viruses in the guinea pig model Tapia, Rodrigo García, Victoria Mena, Juan Bucarey, Sergio Medina, Rafael A. Neira, Víctor Vet Res Short Report Novel H1N2 and H3N2 swine influenza A viruses (IAVs) were identified in commercial farms in Chile. These viruses contained H1, H3 and N2 sequences, genetically divergent from IAVs described worldwide, associated with pandemic internal genes. Guinea pigs were used as human surrogate to evaluate the infection dynamics of these reassortant viruses, compared with a pandemic H1N1 virus. All viruses replicated and were shed in the upper respiratory tract without prior adaptation although H1N2 viruses showed the highest shedding titers. This could have public health importance, emphasizing the need to carry out further studies to evaluate the zoonotic potential of these viruses. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13567-018-0572-4) contains supplementary material, which is available to authorized users. BioMed Central 2018-07-27 2018 /pmc/articles/PMC6062863/ /pubmed/30053826 http://dx.doi.org/10.1186/s13567-018-0572-4 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Tapia, Rodrigo
García, Victoria
Mena, Juan
Bucarey, Sergio
Medina, Rafael A.
Neira, Víctor
Infection of novel reassortant H1N2 and H3N2 swine influenza A viruses in the guinea pig model
title Infection of novel reassortant H1N2 and H3N2 swine influenza A viruses in the guinea pig model
title_full Infection of novel reassortant H1N2 and H3N2 swine influenza A viruses in the guinea pig model
title_fullStr Infection of novel reassortant H1N2 and H3N2 swine influenza A viruses in the guinea pig model
title_full_unstemmed Infection of novel reassortant H1N2 and H3N2 swine influenza A viruses in the guinea pig model
title_short Infection of novel reassortant H1N2 and H3N2 swine influenza A viruses in the guinea pig model
title_sort infection of novel reassortant h1n2 and h3n2 swine influenza a viruses in the guinea pig model
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062863/
https://www.ncbi.nlm.nih.gov/pubmed/30053826
http://dx.doi.org/10.1186/s13567-018-0572-4
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