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Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells

The IRF8-dependent subset of classical dendritic cells (cDCs), termed cDC1, is important for cross-priming cytotoxic T cell responses against pathogens and tumors. Culture of hematopoietic progenitors with DC growth factor FLT3 ligand (FLT3L) yields very few cDC1s (in humans) or only immature “cDC1-...

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Detalles Bibliográficos
Autores principales:	Kirkling, Margaret E., Cytlak, Urszula, Lau, Colleen M., Lewis, Kanako L., Resteu, Anastasia, Khodadadi-Jamayran, Alireza, Siebel, Christian W., Salmon, Hélène, Merad, Miriam, Tsirigos, Aristotelis, Collin, Matthew, Bigley, Venetia, Reizis, Boris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063084/ https://www.ncbi.nlm.nih.gov/pubmed/29925006 http://dx.doi.org/10.1016/j.celrep.2018.05.068

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