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A case series pilot study on the combination of 5-aminolevulinic acid and photodynamic therapy (ALA-PDT) for treatment of vitiligo
BACKGROUND: To study the effective therapeutic concentration, drug application duration, irradiation duration and irradiation dosage of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) for treating vitiligo and observe its clinical efficacy. OBJECTIVE: To assess the clinical efficacy of ALA-PDT...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Dermatologia
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063098/ https://www.ncbi.nlm.nih.gov/pubmed/30066761 http://dx.doi.org/10.1590/abd1806-4841.20187014 |
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author | Zhang, YunJie Lin, Hui Guo, XiaoJuan Zou, XianBiao |
author_facet | Zhang, YunJie Lin, Hui Guo, XiaoJuan Zou, XianBiao |
author_sort | Zhang, YunJie |
collection | PubMed |
description | BACKGROUND: To study the effective therapeutic concentration, drug application duration, irradiation duration and irradiation dosage of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) for treating vitiligo and observe its clinical efficacy. OBJECTIVE: To assess the clinical efficacy of ALA-PDT for treating vitiligo. METHODS: ALA with different drug concentrations, drug application durations, irradiation durations and irradiation dosages were adopted to treat skin lesions caused by vitiligo to determine the effective drug concentration, drug application duration, irradiation duration and irradiation dosage for treating three vitiligo volunteers and observe the therapeutic results. RESULTS: The clinical trial suggested that ALA at a drug concentration of 1.5%, drug application duration for 3 hours, irradiation dosage of 80mw/cm(2) and irradiation duration for 20 min was effective in treating vitiligo. Under these parameters, ALA-PDT was effective to the three vitiligo volunteers, with mild pain and feeling of burning but no other adverse reaction during treatment. STUDY LIMITATIONS: Due to the small sample size in this study for the effectiveness of PDT in treating vitiligo and the potential variations in the efficacy for treating the disease at different areas, further studies shall be conducted for confirmation. CONCLUSIONS: ALA with a drug concentration at 1.5%, drug application duration for 3 hours, irradiation dosage of 80 mw/cm(2) and irradiation duration for 20 min is effective in treating vitiligo. Therefore, ALA-PDT is safe and effective in treating the disease, with minor adverse events, providing a new method for treating vitiligo in the future. |
format | Online Article Text |
id | pubmed-6063098 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Sociedade Brasileira de Dermatologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-60630982018-08-07 A case series pilot study on the combination of 5-aminolevulinic acid and photodynamic therapy (ALA-PDT) for treatment of vitiligo Zhang, YunJie Lin, Hui Guo, XiaoJuan Zou, XianBiao An Bras Dermatol Investigation BACKGROUND: To study the effective therapeutic concentration, drug application duration, irradiation duration and irradiation dosage of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) for treating vitiligo and observe its clinical efficacy. OBJECTIVE: To assess the clinical efficacy of ALA-PDT for treating vitiligo. METHODS: ALA with different drug concentrations, drug application durations, irradiation durations and irradiation dosages were adopted to treat skin lesions caused by vitiligo to determine the effective drug concentration, drug application duration, irradiation duration and irradiation dosage for treating three vitiligo volunteers and observe the therapeutic results. RESULTS: The clinical trial suggested that ALA at a drug concentration of 1.5%, drug application duration for 3 hours, irradiation dosage of 80mw/cm(2) and irradiation duration for 20 min was effective in treating vitiligo. Under these parameters, ALA-PDT was effective to the three vitiligo volunteers, with mild pain and feeling of burning but no other adverse reaction during treatment. STUDY LIMITATIONS: Due to the small sample size in this study for the effectiveness of PDT in treating vitiligo and the potential variations in the efficacy for treating the disease at different areas, further studies shall be conducted for confirmation. CONCLUSIONS: ALA with a drug concentration at 1.5%, drug application duration for 3 hours, irradiation dosage of 80 mw/cm(2) and irradiation duration for 20 min is effective in treating vitiligo. Therefore, ALA-PDT is safe and effective in treating the disease, with minor adverse events, providing a new method for treating vitiligo in the future. Sociedade Brasileira de Dermatologia 2018 /pmc/articles/PMC6063098/ /pubmed/30066761 http://dx.doi.org/10.1590/abd1806-4841.20187014 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivative License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited and the work is not changed in any way. |
spellingShingle | Investigation Zhang, YunJie Lin, Hui Guo, XiaoJuan Zou, XianBiao A case series pilot study on the combination of 5-aminolevulinic acid and photodynamic therapy (ALA-PDT) for treatment of vitiligo |
title | A case series pilot study on the combination of 5-aminolevulinic acid
and photodynamic therapy (ALA-PDT) for treatment of vitiligo |
title_full | A case series pilot study on the combination of 5-aminolevulinic acid
and photodynamic therapy (ALA-PDT) for treatment of vitiligo |
title_fullStr | A case series pilot study on the combination of 5-aminolevulinic acid
and photodynamic therapy (ALA-PDT) for treatment of vitiligo |
title_full_unstemmed | A case series pilot study on the combination of 5-aminolevulinic acid
and photodynamic therapy (ALA-PDT) for treatment of vitiligo |
title_short | A case series pilot study on the combination of 5-aminolevulinic acid
and photodynamic therapy (ALA-PDT) for treatment of vitiligo |
title_sort | case series pilot study on the combination of 5-aminolevulinic acid
and photodynamic therapy (ala-pdt) for treatment of vitiligo |
topic | Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063098/ https://www.ncbi.nlm.nih.gov/pubmed/30066761 http://dx.doi.org/10.1590/abd1806-4841.20187014 |
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