Paget's Disease of Bone: An Entity Still Exists in India

BACKGROUND: Paget's disease of bone (PDB) is uncommonly reported from India. We attempted to study the clinical and imaging features and management of participants who presented with PDB. MATERIALS AND METHODS: In this retrospective study, clinical and imaging profile, biochemistry, and treatme...

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Detalles Bibliográficos
Autores principales: Cherian, Kripa Elizabeth, Kapoor, Nitin, Shetty, Sahana, Jebasingh, Felix K., Asha, Hesarghatta Shyamasunder, Hephzibah, Julie, Prabhu, Anne Jennifer, Rajaratnam, Simon, Thomas, Nihal, Paul, Thomas Vizhalil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063169/
https://www.ncbi.nlm.nih.gov/pubmed/30090729
http://dx.doi.org/10.4103/ijem.IJEM_19_18
Descripción
Sumario:BACKGROUND: Paget's disease of bone (PDB) is uncommonly reported from India. We attempted to study the clinical and imaging features and management of participants who presented with PDB. MATERIALS AND METHODS: In this retrospective study, clinical and imaging profile, biochemistry, and treatment outcomes of participants with PDB (n = 48) were obtained. RESULTS: The mean age was 60 ± 11.3 years and 35% were women. Twenty percent were asymptomatic. Many (87%) had polyostotic involvement. Sixty percent (n = 29) underwent treatment with zoledronic acid and rest with oral bisphosphonates, and all achieved remission. CONCLUSION: Most of the pagetic participants had polyostotic disease and one-fifth were asymptomatic. All participants had disease remission following treatment.

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