The impact of single-cell RNA sequencing on understanding the functional organization of the immune system

Application of single-cell genomics technologies has revolutionized our approach to study the immune system. Unravelling the functional diversity of immune cells and their coordinated response is key to understanding immunity. Single-cell transcriptomics technologies provide high-dimensional assessm...

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Detalles Bibliográficos
Autores principales: Vegh, Peter, Haniffa, Muzlifah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063276/
https://www.ncbi.nlm.nih.gov/pubmed/29547972
http://dx.doi.org/10.1093/bfgp/ely003
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author Vegh, Peter
Haniffa, Muzlifah
author_facet Vegh, Peter
Haniffa, Muzlifah
author_sort Vegh, Peter
collection PubMed
description Application of single-cell genomics technologies has revolutionized our approach to study the immune system. Unravelling the functional diversity of immune cells and their coordinated response is key to understanding immunity. Single-cell transcriptomics technologies provide high-dimensional assessment of the transcriptional states of immune cells and have been successfully applied to discover new immune cell types, reveal haematopoietic lineages, identify gene modules dictating immune responses and investigate lymphocyte antigen receptor diversity. In this review, we discuss the impact and applications of single-cell RNA sequencing technologies in immunology.
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spelling pubmed-60632762018-08-08 The impact of single-cell RNA sequencing on understanding the functional organization of the immune system Vegh, Peter Haniffa, Muzlifah Brief Funct Genomics Papers Application of single-cell genomics technologies has revolutionized our approach to study the immune system. Unravelling the functional diversity of immune cells and their coordinated response is key to understanding immunity. Single-cell transcriptomics technologies provide high-dimensional assessment of the transcriptional states of immune cells and have been successfully applied to discover new immune cell types, reveal haematopoietic lineages, identify gene modules dictating immune responses and investigate lymphocyte antigen receptor diversity. In this review, we discuss the impact and applications of single-cell RNA sequencing technologies in immunology. Oxford University Press 2018-03-14 /pmc/articles/PMC6063276/ /pubmed/29547972 http://dx.doi.org/10.1093/bfgp/ely003 Text en © The Author(s) 2018. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Papers
Vegh, Peter
Haniffa, Muzlifah
The impact of single-cell RNA sequencing on understanding the functional organization of the immune system
title The impact of single-cell RNA sequencing on understanding the functional organization of the immune system
title_full The impact of single-cell RNA sequencing on understanding the functional organization of the immune system
title_fullStr The impact of single-cell RNA sequencing on understanding the functional organization of the immune system
title_full_unstemmed The impact of single-cell RNA sequencing on understanding the functional organization of the immune system
title_short The impact of single-cell RNA sequencing on understanding the functional organization of the immune system
title_sort impact of single-cell rna sequencing on understanding the functional organization of the immune system
topic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063276/
https://www.ncbi.nlm.nih.gov/pubmed/29547972
http://dx.doi.org/10.1093/bfgp/ely003
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