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The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines

High histone deacetylase (HDAC) 8 and HDAC10 expression levels have been identified as predictors of exceptionally poor outcomes in neuroblastoma, the most common extracranial solid tumor in childhood. HDAC8 inhibition synergizes with retinoic acid treatment to induce neuroblast maturation in vitro...

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Detalles Bibliográficos
Autores principales:	Kolbinger, Fiona R., Koeneke, Emily, Ridinger, Johannes, Heimburg, Tino, Müller, Michael, Bayer, Theresa, Sippl, Wolfgang, Jung, Manfred, Gunkel, Nikolas, Miller, Aubry K., Westermann, Frank, Witt, Olaf, Oehme, Ina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2018
Materias:	Genotoxicity and Carcinogenicity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063332/ https://www.ncbi.nlm.nih.gov/pubmed/29947893 http://dx.doi.org/10.1007/s00204-018-2234-8

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