Toxicity, recovery, and resilience in a 3D dopaminergic neuronal in vitro model exposed to rotenone

To date, most in vitro toxicity testing has focused on acute effects of compounds at high concentrations. This testing strategy does not reflect real-life exposures, which might contribute to long-term disease outcome. We used a 3D-human dopaminergic in vitro LUHMES cell line model to determine whet...

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Detalles Bibliográficos
Autores principales: Harris, Georgina, Eschment, Melanie, Orozco, Sebastian Perez, McCaffery, J. Michael, Maclennan, Richard, Severin, Daniel, Leist, Marcel, Kleensang, Andre, Pamies, David, Maertens, Alexandra, Hogberg, Helena T., Freeman, Dana, Kirkwood, Alfredo, Hartung, Thomas, Smirnova, Lena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
In Vitro Systems
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063347/
https://www.ncbi.nlm.nih.gov/pubmed/29955902
http://dx.doi.org/10.1007/s00204-018-2250-8

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