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Thiol-maleimide poly(ethylene glycol) crosslinking of L-asparaginase subunits at recombinant cysteine residues introduced by mutagenesis

L-Asparaginase is an enzyme successfully being used in the treatment of acute lymphoblastic leukemia, acute myeloid leukemia, and non-Hodgkin’s lymphoma. However, some disadvantages still limit its full application potential, e.g., allergic reactions, pancreatitis, and blood clotting impairment. The...

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Detalles Bibliográficos
Autores principales:	Ramirez-Paz, Josell, Saxena, Manoj, Delinois, Louis J., Joaquín-Ovalle, Freisa M., Lin, Shiru, Chen, Zhongfang, Rojas-Nieves, Virginia A., Griebenow, Kai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063399/ https://www.ncbi.nlm.nih.gov/pubmed/30052638 http://dx.doi.org/10.1371/journal.pone.0197643

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