Cationic Amphiphilic Bolaamphiphile-based Delivery of Antisense Oligonucleotides Provides a Potentially Microbiome Sparing Treatment for C. difficile

Conventional antibiotics for C. difficile infection (CDI) have mechanisms of action without organismal specificity, potentially perpetuating the dysbiosis contributing to CDI, making antisense approaches an attractive alternative. Here, three (APDE-8, CODE-9, CYDE-21) novel cationic amphiphilic bola...

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Detalles Bibliográficos
Autores principales: Sharma, Arun K., Krzeminski, Jacek, Weissig, Volkmar, Hegarty, John P., Stewart, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063762/
https://www.ncbi.nlm.nih.gov/pubmed/29674636
http://dx.doi.org/10.1038/s41429-018-0056-9

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