Human Carbonic Anhydrase-8 AAV8 Gene Therapy Inhibits Nerve Growth Factor Signaling Producing Prolonged Analgesia and Anti-Hyperalgesia in Mice

Carbonic anhydrase-8 (Car8; murine gene symbol) is an allosteric inhibitor of inositol trisphosphate receptor-1 (ITPR1), which regulates neuronal intracellular calcium release. We previously reported that wildtype Car8 overexpression corrects the baseline allodynia and hyperalgesia associated with c...

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Detalles Bibliográficos
Autores principales: Zhuang, Gerald Z., Upadhyay, Udita, Tong, Xiaoying, Kang, Yuan, Erasso, Diana M., Fu, Eugene S., Sarantopoulos, Konstantinos D., Martin, Eden R., Wiltshire, Tim, Diatchenko, Luda, Smith, Shad B, Maixner, William, Levitt, Roy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063772/
https://www.ncbi.nlm.nih.gov/pubmed/29789638
http://dx.doi.org/10.1038/s41434-018-0018-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063772/
https://www.ncbi.nlm.nih.gov/pubmed/29789638
http://dx.doi.org/10.1038/s41434-018-0018-7

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