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Human Carbonic Anhydrase-8 AAV8 Gene Therapy Inhibits Nerve Growth Factor Signaling Producing Prolonged Analgesia and Anti-Hyperalgesia in Mice
Carbonic anhydrase-8 (Car8; murine gene symbol) is an allosteric inhibitor of inositol trisphosphate receptor-1 (ITPR1), which regulates neuronal intracellular calcium release. We previously reported that wildtype Car8 overexpression corrects the baseline allodynia and hyperalgesia associated with c...
Autores principales: | Zhuang, Gerald Z., Upadhyay, Udita, Tong, Xiaoying, Kang, Yuan, Erasso, Diana M., Fu, Eugene S., Sarantopoulos, Konstantinos D., Martin, Eden R., Wiltshire, Tim, Diatchenko, Luda, Smith, Shad B, Maixner, William, Levitt, Roy C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063772/ https://www.ncbi.nlm.nih.gov/pubmed/29789638 http://dx.doi.org/10.1038/s41434-018-0018-7 |
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