Comprehensive organic profiling of biological particles derived from blood

Mineral nanoparticles form in physiological and pathological processes occurring in the human body. The calcium phosphate mineral phase of the particles has affinity for proteins and lipids, but the complete profiling of the organic molecules that bind to the particles has not been described in deta...

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Autores principales: Wu, Cheng-Yeu, Martel, Jan, Young, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063858/
https://www.ncbi.nlm.nih.gov/pubmed/30054526
http://dx.doi.org/10.1038/s41598-018-29573-6
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author Wu, Cheng-Yeu
Martel, Jan
Young, John D.
author_facet Wu, Cheng-Yeu
Martel, Jan
Young, John D.
author_sort Wu, Cheng-Yeu
collection PubMed
description Mineral nanoparticles form in physiological and pathological processes occurring in the human body. The calcium phosphate mineral phase of the particles has affinity for proteins and lipids, but the complete profiling of the organic molecules that bind to the particles has not been described in detail. We report here a comprehensive analysis of organic components found in mineralo-organic particles derived from body fluids. Based on biological staining, fluorescent tagging, proteomics and metabolomics, our results indicate that the mineral particles bind to proteins, amino acids, carbohydrates, polysaccharides, phospholipids, fatty acids, DNA and low molecular weight metabolites. These results can be used to study the formation and effects of mineralo-organic particles in biological fluids.
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spelling pubmed-60638582018-07-31 Comprehensive organic profiling of biological particles derived from blood Wu, Cheng-Yeu Martel, Jan Young, John D. Sci Rep Article Mineral nanoparticles form in physiological and pathological processes occurring in the human body. The calcium phosphate mineral phase of the particles has affinity for proteins and lipids, but the complete profiling of the organic molecules that bind to the particles has not been described in detail. We report here a comprehensive analysis of organic components found in mineralo-organic particles derived from body fluids. Based on biological staining, fluorescent tagging, proteomics and metabolomics, our results indicate that the mineral particles bind to proteins, amino acids, carbohydrates, polysaccharides, phospholipids, fatty acids, DNA and low molecular weight metabolites. These results can be used to study the formation and effects of mineralo-organic particles in biological fluids. Nature Publishing Group UK 2018-07-27 /pmc/articles/PMC6063858/ /pubmed/30054526 http://dx.doi.org/10.1038/s41598-018-29573-6 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Wu, Cheng-Yeu
Martel, Jan
Young, John D.
Comprehensive organic profiling of biological particles derived from blood
title Comprehensive organic profiling of biological particles derived from blood
title_full Comprehensive organic profiling of biological particles derived from blood
title_fullStr Comprehensive organic profiling of biological particles derived from blood
title_full_unstemmed Comprehensive organic profiling of biological particles derived from blood
title_short Comprehensive organic profiling of biological particles derived from blood
title_sort comprehensive organic profiling of biological particles derived from blood
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063858/
https://www.ncbi.nlm.nih.gov/pubmed/30054526
http://dx.doi.org/10.1038/s41598-018-29573-6
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