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TGF‐β–responsive CAR‐T cells promote anti‐tumor immune function

A chimeric antigen receptor (CAR) that responds to transforming growth factor beta (TGF‐β) enables the engineering of T cells that convert this immunosuppressive cytokine into a potent T‐cell stimulant. However, clinical translation of TGF‐β CAR‐T cells for cancer therapy requires the ability to pro...

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Detalles Bibliográficos
Autores principales:	Hou, Andrew J., Chang, ZeNan L., Lorenzini, Michael H., Zah, Eugenia, Chen, Yvonne Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Research Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063867/ https://www.ncbi.nlm.nih.gov/pubmed/30065964 http://dx.doi.org/10.1002/btm2.10097

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