Propolis: Chemical Composition and Its Applications in Endodontics

INTRODUCTION: The aim of this study was to review the chemical composition of propolis and its application in endodontics. METHODS AND MATERIALS: For this purpose, keywords were searched on ScienceDirect, PubMed and World of Chemicals databases in order to find published papers from 1988 to February 2018. RESULTS: There are many different compounds in propolis of different geographic regions; flavonoids are one of the most important agents which have anti-inflammatory, anti-viral, anti-allergic, anti-cancer, anti-bacterial and antioxidant effects. According to the mentioned properties, propolis can be used as a canal irrigation solution as well as intracanal medicament in endodontic treatments. Studies have shown that propolis as a storage medium is capable of maintaining the vitality of the periodontal ligaments cells and also has the ability to inhibit osteoclastic activity due to one of the active compounds present in it. In vital pulp therapy, propolis can induce the production of tubular dentin and also decrease the inflammation of the pulp. CONCLUSION: Considering the propolis components like resin, pollen, vitamins, flavonoids and phenols; it can be used for various purposes in endodontics and would have a promising role in future medicine as well as dentistry.