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Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis

BACKGROUND: Alzheimer’s disease (AD), the most common cause of dementia, is characterized by the progressive deposition of amyloid-β (Aβ) peptides and neurofibrillary tangles. Mouse models of Aβ amyloidosis generated by knock-in (KI) of a humanized Aβ sequence provide distinct advantages over tradit...

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Detalles Bibliográficos
Autores principales:	Sakakibara, Yasufumi, Sekiya, Michiko, Saito, Takashi, Saido, Takaomi C., Iijima, Koichi M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064053/ https://www.ncbi.nlm.nih.gov/pubmed/30055565 http://dx.doi.org/10.1186/s12868-018-0446-8

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