The impact of ABCB1 (rs1045642 and rs4148738) and CES1 (rs2244613) gene polymorphisms on dabigatran equilibrium peak concentration in patients after total knee arthroplasty

BACKGROUND: Non-vitamin K oral anticoagulants (NOACs) are commonly used for prophylaxis of venous thromboembolism (VTE) in orthopedic patients. Despite known safety and high potency of NOACs, potential interactions of NOACs with genetic polymorphisms are poorly understood. Dabigatran etexilate is on...

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Detalles Bibliográficos
Autores principales: Sychev, Dmitriy Alekseevich, Levanov, Alexander Nikolaevich, Shelekhova, Tatiana Vladimirovna, Bochkov, Pavel Olegovich, Denisenko, Natalia Pavlovna, Ryzhikova, Kristina Anatolyevna, Mirzaev, Karin Badavievich, Grishina, Elena Anatolyevna, Gavrilov, Mikhail Alekseevich, Ramenskaya, Galina Vladislavovna, Kozlov, Aleksei Vladimirovich, Bogoslovsky, Tanya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064159/
https://www.ncbi.nlm.nih.gov/pubmed/30100750
http://dx.doi.org/10.2147/PGPM.S169277

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