Cargando…

Adenosine 5’-triphosphate’s role in bradycardia and syncope associated with pulmonary embolism

Adenosine 5′-triphiosphate (ATP) is released from cells under physiologic and pathophysiologic conditions. Extracellular ATP acts as an autocrine and paracrine agent affecting various cell types by activating cell surface P2 receptors (P2R), which include trans-cell membrane cationic channels, P2XR,...

Descripción completa

Detalles Bibliográficos
Autores principales: Pelleg, Amir, Schulman, Edward S., Barnes, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064160/
https://www.ncbi.nlm.nih.gov/pubmed/30055609
http://dx.doi.org/10.1186/s12931-018-0848-2
_version_ 1783342678516170752
author Pelleg, Amir
Schulman, Edward S.
Barnes, Peter J.
author_facet Pelleg, Amir
Schulman, Edward S.
Barnes, Peter J.
author_sort Pelleg, Amir
collection PubMed
description Adenosine 5′-triphiosphate (ATP) is released from cells under physiologic and pathophysiologic conditions. Extracellular ATP acts as an autocrine and paracrine agent affecting various cell types by activating cell surface P2 receptors (P2R), which include trans-cell membrane cationic channels, P2XR, and G protein coupled receptors, P2YR. We have previously shown that ATP stimulates vagal afferent nerve terminals in the lungs by activating P2X2/3R. This action could lead to bronchoconstriction, cough and the local release of pro-inflammatory neuropeptides. In addition, ATP markedly enhances the IgE-dependent histamine release from human lung mast cells. Thus, we have proposed for the first time that extracellular ATP plays a mechanistic role in pulmonary pathophysiology in general and chronic obstructive pulmonary disease (COPD), and acute bronchoconstriction in asthma in particular. The present review examines whether ATP could also play a role in bradycardia and syncope in a subset of patients with pulmonary embolism.
format Online
Article
Text
id pubmed-6064160
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-60641602018-08-01 Adenosine 5’-triphosphate’s role in bradycardia and syncope associated with pulmonary embolism Pelleg, Amir Schulman, Edward S. Barnes, Peter J. Respir Res Commentary Adenosine 5′-triphiosphate (ATP) is released from cells under physiologic and pathophysiologic conditions. Extracellular ATP acts as an autocrine and paracrine agent affecting various cell types by activating cell surface P2 receptors (P2R), which include trans-cell membrane cationic channels, P2XR, and G protein coupled receptors, P2YR. We have previously shown that ATP stimulates vagal afferent nerve terminals in the lungs by activating P2X2/3R. This action could lead to bronchoconstriction, cough and the local release of pro-inflammatory neuropeptides. In addition, ATP markedly enhances the IgE-dependent histamine release from human lung mast cells. Thus, we have proposed for the first time that extracellular ATP plays a mechanistic role in pulmonary pathophysiology in general and chronic obstructive pulmonary disease (COPD), and acute bronchoconstriction in asthma in particular. The present review examines whether ATP could also play a role in bradycardia and syncope in a subset of patients with pulmonary embolism. BioMed Central 2018-07-28 2018 /pmc/articles/PMC6064160/ /pubmed/30055609 http://dx.doi.org/10.1186/s12931-018-0848-2 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Pelleg, Amir
Schulman, Edward S.
Barnes, Peter J.
Adenosine 5’-triphosphate’s role in bradycardia and syncope associated with pulmonary embolism
title Adenosine 5’-triphosphate’s role in bradycardia and syncope associated with pulmonary embolism
title_full Adenosine 5’-triphosphate’s role in bradycardia and syncope associated with pulmonary embolism
title_fullStr Adenosine 5’-triphosphate’s role in bradycardia and syncope associated with pulmonary embolism
title_full_unstemmed Adenosine 5’-triphosphate’s role in bradycardia and syncope associated with pulmonary embolism
title_short Adenosine 5’-triphosphate’s role in bradycardia and syncope associated with pulmonary embolism
title_sort adenosine 5’-triphosphate’s role in bradycardia and syncope associated with pulmonary embolism
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064160/
https://www.ncbi.nlm.nih.gov/pubmed/30055609
http://dx.doi.org/10.1186/s12931-018-0848-2
work_keys_str_mv AT pellegamir adenosine5triphosphatesroleinbradycardiaandsyncopeassociatedwithpulmonaryembolism
AT schulmanedwards adenosine5triphosphatesroleinbradycardiaandsyncopeassociatedwithpulmonaryembolism
AT barnespeterj adenosine5triphosphatesroleinbradycardiaandsyncopeassociatedwithpulmonaryembolism