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Concurrent Autoimmune Neutropenia and Idiopathic Thrombocytopenic Purpura Associated with IgG4-related Diease

IgG4-related disease (IgG4RD) is a multi-organ disorder characterized by an elevated serum IgG4 level and IgG4-positive plasma cell infiltration of the affected organs, accompanied by tissue fibrosis and sclerosis. Although it can affect any organ, to our knowledge, no cases involving concurrent aut...

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Autores principales: Shimazu, Yayoi, Uchiyama, Tatsuki, Mizumoto, Chisaki, Takeoka, Tomoharu, Tsuji, Masaaki, Tomo, Kenjiro, Takaori, Koji, Sakai, Naoki, Okuno, Tomoko, Ohno, Tatsuharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064692/
https://www.ncbi.nlm.nih.gov/pubmed/29491289
http://dx.doi.org/10.2169/internalmedicine.0190-17
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author Shimazu, Yayoi
Uchiyama, Tatsuki
Mizumoto, Chisaki
Takeoka, Tomoharu
Tsuji, Masaaki
Tomo, Kenjiro
Takaori, Koji
Sakai, Naoki
Okuno, Tomoko
Ohno, Tatsuharu
author_facet Shimazu, Yayoi
Uchiyama, Tatsuki
Mizumoto, Chisaki
Takeoka, Tomoharu
Tsuji, Masaaki
Tomo, Kenjiro
Takaori, Koji
Sakai, Naoki
Okuno, Tomoko
Ohno, Tatsuharu
author_sort Shimazu, Yayoi
collection PubMed
description IgG4-related disease (IgG4RD) is a multi-organ disorder characterized by an elevated serum IgG4 level and IgG4-positive plasma cell infiltration of the affected organs, accompanied by tissue fibrosis and sclerosis. Although it can affect any organ, to our knowledge, no cases involving concurrent autoimmune neutropenia and thrombocytopenia have been reported. A 62-year-old man visited our hospital and was diagnosed with IgG4RD accompanied by interstitial pneumonitis, lymphadenopathy, and interstitial nephritis. During his clinical course, he developed autoimmune neutropenia and idiopathic thrombocytopenic purpura. Our case, invoving multiple hematological abnormalities, might help deepen our understanding of the pathophysiology of IgG4RD.
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spelling pubmed-60646922018-07-30 Concurrent Autoimmune Neutropenia and Idiopathic Thrombocytopenic Purpura Associated with IgG4-related Diease Shimazu, Yayoi Uchiyama, Tatsuki Mizumoto, Chisaki Takeoka, Tomoharu Tsuji, Masaaki Tomo, Kenjiro Takaori, Koji Sakai, Naoki Okuno, Tomoko Ohno, Tatsuharu Intern Med Case Report IgG4-related disease (IgG4RD) is a multi-organ disorder characterized by an elevated serum IgG4 level and IgG4-positive plasma cell infiltration of the affected organs, accompanied by tissue fibrosis and sclerosis. Although it can affect any organ, to our knowledge, no cases involving concurrent autoimmune neutropenia and thrombocytopenia have been reported. A 62-year-old man visited our hospital and was diagnosed with IgG4RD accompanied by interstitial pneumonitis, lymphadenopathy, and interstitial nephritis. During his clinical course, he developed autoimmune neutropenia and idiopathic thrombocytopenic purpura. Our case, invoving multiple hematological abnormalities, might help deepen our understanding of the pathophysiology of IgG4RD. The Japanese Society of Internal Medicine 2018-02-28 2018-07-01 /pmc/articles/PMC6064692/ /pubmed/29491289 http://dx.doi.org/10.2169/internalmedicine.0190-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Shimazu, Yayoi
Uchiyama, Tatsuki
Mizumoto, Chisaki
Takeoka, Tomoharu
Tsuji, Masaaki
Tomo, Kenjiro
Takaori, Koji
Sakai, Naoki
Okuno, Tomoko
Ohno, Tatsuharu
Concurrent Autoimmune Neutropenia and Idiopathic Thrombocytopenic Purpura Associated with IgG4-related Diease
title Concurrent Autoimmune Neutropenia and Idiopathic Thrombocytopenic Purpura Associated with IgG4-related Diease
title_full Concurrent Autoimmune Neutropenia and Idiopathic Thrombocytopenic Purpura Associated with IgG4-related Diease
title_fullStr Concurrent Autoimmune Neutropenia and Idiopathic Thrombocytopenic Purpura Associated with IgG4-related Diease
title_full_unstemmed Concurrent Autoimmune Neutropenia and Idiopathic Thrombocytopenic Purpura Associated with IgG4-related Diease
title_short Concurrent Autoimmune Neutropenia and Idiopathic Thrombocytopenic Purpura Associated with IgG4-related Diease
title_sort concurrent autoimmune neutropenia and idiopathic thrombocytopenic purpura associated with igg4-related diease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064692/
https://www.ncbi.nlm.nih.gov/pubmed/29491289
http://dx.doi.org/10.2169/internalmedicine.0190-17
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